Evidence map›Paper›PMID 31122230›Full record

ArticleBMC pulmonary medicine2019

Omega-3 fatty acid intake and prevalent respiratory symptoms among U.S. adults with COPD.

Chantal M Lemoine S, Emily P Brigham, Han Woo, Corrine K Hanson, Meredith C McCormack, Abigail Koch, Nirupama Putcha, Nadia N Hansel

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04042519 (The Correlation Research Between the Omega-3 and Omega-6 Inflammatory Metabolites and Stable COPD.), which is not on this map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04042519 completednot on this map

The Correlation Research Between the Omega-3 and Omega-6 Inflammatory Metabolites and Stable COPD.

TypeobservationalSponsorGuangzhou Institute of Respiratory DiseaseRan2016 to 2019Enrolled200ConditionsMetabolomics, Omega 6, Omega 3, COPDArmsLung function test was performed on the subjects with Jaeger lung function instrument of Germany., Agilent 1290 Infinity LC system (UHPLC, Santa Clara CA) was used for Targeted metabolite detection., Routine blood test
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Functional Food Ingredients Enhancing Immune Health.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Food Insecurity is Associated With COPD Morbidity and Perceived Stress.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chantal M Lemoine SJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Emily P BrighamJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Han WooJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Corrine K HansonUniversity of Nebraska Medical Center, Omaha, NE, USA.
Meredith C McCormackJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Abigail KochJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Nirupama PutchaJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Nadia N HanselJohns Hopkins University School of Medicine, Baltimore, MD, USA. nhansel1@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · USUniversity of Nebraska Medical Center · US

Funding

Institute for Clinical and Translational ResearchKL2TR001077 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$9.2M
The role of obesity in biological responses to particulate matter in miceP50ES018176 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2015 to 2019
$4.8M
The Environmental Assessments Core (FSC)P50MD010431 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI MATSUI, ELIZABETH C. · 2015 to 2019
$3.5M
Relationship Between Indoor Ultrafine Particle Exposure and Respiratory Morbidity, Inflammation, and Oxidative Stress in Children with AsthmaK23ES029105 · NIEHS · UNIVERSITY OF BRITISH COLUMBIA · PI BRIGHAM, EMILY · 2019 to 2022
$755k
NCATS NIH HHS KL2 TR001077NIEHS NIH HHS K23 ES029105NIEHS NIH HHS P50 ES018176NIMHD NIH HHS P50 MD010431U.S. Environmental Protection Agency 83451001U.S. Environmentat Protection Agency 83615201
6 · The paper itself

Abstract

backgroundOmega-3 fatty acids, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and derivatives, play a key role in the resolution of inflammation. Higher intake has been linked to decreased morbidity in several diseases, though effects on respiratory diseases like COPD are understudied.

methodsThe National Health and Nutrition Examination Survey (NHANES), with a focus on dietary assessment, provides a unique opportunity to explore relationships between omega-3 intake and morbidity in respiratory diseases marked by inflammation in the United States (US) population. We investigated relationships between ALA or EPA + DHA intake and respiratory symptoms among US adults with COPD, as well as variation in relationships based on personal characteristics or exposures.

resultsOf 878 participants, mean age was 60.6 years, 48% were current smokers, and 68% completed high school. Omega-3 intake was, 1.71 ± 0.89 g (ALA), and 0.11 ± 0.21 g (EPA + DHA). Logistic regression models, adjusting for age, gender, race, body mass index, FEV

conclusionsIndividual factors should be taken into consideration when studying the association of fatty acid intake on respiratory diseases, as differential responses may reveal susceptible subgroups.

Indexed as

Dietary SupplementsAgedalpha-Linolenic AcidCoughCross-Sectional StudiesDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3FemaleHumansLogistic ModelsMaleMiddle AgedNutrition SurveysPulmonary Disease, Chronic ObstructiveRespiratory Function Testsalpha-Linolenic AcidDocosahexaenoic AcidsEicosapentaenoic Acideicosapentaenoic acid ethyl esterFatty Acids, Omega-3COPDEducationFatty acidOmegaSmoking

Identifiers

PMID31122230
PMCPMC6533751
OpenAlexW2947283569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.