Evidence map›Paper›PMID 31122208›Full record

ArticleBMC genomics2019

Comparative genome analysis of the Lactobacillus brevis species.

Marine Feyereisen, Jennifer Mahony, Philip Kelleher, Richard John Roberts, Tadhg O'Sullivan, Jan-Maarten A Geertman, Douwe van Sinderen

Open access · goldAbstract read
In one paragraph

Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 56 citations in OpenAlex.

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  12. Volatile Organic Compounds (VOCs) Produced byMolecules (Basel, Switzerland) · 2024
    Article
  13. Review
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  15. Frontiers in microbiology · 2023
    Article
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  18. Identification of Type II Toxin-Antitoxin Loci in Levilactobacillus brevis.Interdisciplinary sciences, computational life sciences · 2022
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Marine FeyereisenSchool of Microbiology, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0002-5108-4238
Jennifer MahonySchool of Microbiology, University College Cork, Cork, Ireland.
Philip KelleherSchool of Microbiology, University College Cork, Cork, Ireland.
Richard John RobertsNew England BioLabs, Inc., Ipswich, MA, USA.
Tadhg O'SullivanHEINEKEN Global Supply Chain B.V, Zoeterwoude, The Netherlands.
Jan-Maarten A GeertmanHEINEKEN Global Supply Chain B.V, Zoeterwoude, The Netherlands.
Douwe van SinderenSchool of Microbiology, University College Cork, Cork, Ireland. d.vansinderen@ucc.ie.
University College Cork · IEHeineken (Netherlands) · NLNew England Biolabs (United States) · US

Funding

Irish Research Council EPSPG/2015/7Science Foundation Ireland 15/SIRG/3430Science Foundation Ireland 450 13/IA/1953
6 · The paper itself

Abstract

backgroundLactobacillus brevis is a member of the lactic acid bacteria (LAB), and strains of L. brevis have been isolated from silage, as well as from fermented cabbage and other fermented foods. However, this bacterium is also commonly associated with bacterial spoilage of beer.

resultsIn the current study, complete genome sequences of six isolated L. brevis strains were determined. Five of these L. brevis strains were isolated from beer (three isolates) or the brewing environment (two isolates), and were characterized as beer-spoilers or non-beer spoilers, respectively, while the sixth isolate had previously been isolated from silage. The genomic features of 19 L. brevis strains, encompassing the six L. brevis strains described in this study and thirteen L. brevis strains for which complete genome sequences were available in public databases, were analyzed with particular attention to evolutionary aspects and adaptation to beer.

conclusionsComparative genomic analysis highlighted evolution of the taxon allowing niche colonization, notably adaptation to the beer environment, with approximately 50 chromosomal genes acquired by L. brevis beer-spoiler strains representing approximately 2% of their total chromosomal genetic content. These genes primarily encode proteins that are putatively involved in oxidation-reduction reactions, transcription regulation or membrane transport, functions that may be crucial to survive the harsh conditions associated with beer. The study emphasized the role of plasmids in beer spoilage with a number of unique genes identified among L. brevis beer-spoiler strains.

Indexed as

Genome, BacterialBeerEvolution, MolecularGenes, BacterialLevilactobacillus brevisPhylogenyPlasmidsBeer adaptationBeer spoilageGenomicsLactobacillus brevisPan-genomeSMRT sequencing

Identifiers

PMID31122208
PMCPMC6533708
OpenAlexW2947179372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.