Trial reportThe journal of headache and pain2019
The effect of CSF drain on the optic nerve in idiopathic intracranial hypertension.
Trial report in The journal of headache and pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- MRI-based evaluation of cerebrospinal fluid dynamics and optic nerve subarachnoid space alterations in idiopathic intracranial hypertension and normal tension glaucoma: a systematic review.BMC medical imaging · 2026Pooled it
- Trial
- Evaluation of postoperative nerve root oedema and analysis of risk factors in unilateral biportal endoscopic discectomy using the DESS sequence: preliminary results.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Glymphatic system impairment in dysthyroid optic neuropathy: relation with ocular cerebrospinal fluid circulation and visual function.Japanese journal of radiology · 2026Article
- Cervical Oculopathy: The Cervical Spine Etiology of Visual Symptoms and Eye Diseases-A Hypothesis Exploring Mechanisms Linking the Neck and the Eye.Diagnostics (Basel, Switzerland) · 2025Article
- Objective test findings in patients with chronic eye symptoms seeking care at an outpatient neck center: ligamentous cervical instability etiology?Frontiers in neurology · 2025Article
- Which Theory of Cerebrospinal Fluid Production and Absorption Do Neurosurgeons Teach to Medical Students? Survey from Medical Universities in Japan, 2022.Neurologia medico-chirurgica · 2024Article
- Can optic disc vessel density help in cases of residual disc elevation after shunt surgery in cases of idiopathic intracranial hypertension?Lasers in medical science · 2024Article
- Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature.Fluids and barriers of the CNS · 2024Article
- Optic Nerve Head Changes Measured by Swept Source Optical Coherence Tomography and Angiography in Patients with Intracranial Hypertension.Ophthalmology and therapy · 2023Article
- Update on Idiopathic Intracranial Hypertension Management.Arquivos de neuro-psiquiatria · 2022Review
- Diagnosis and treatment of idiopathic intracranial hypertension.Cephalalgia : an international journal of headache · 2021Review
- Quantitative magnetic resonance image assessment of the optic nerve and surrounding sheath after spaceflight.NPJ microgravity · 2020Article
- An Update on Imaging in Idiopathic Intracranial Hypertension.Frontiers in neurology · 2020Review
- Pathogenesis and Evaluation of the Effects of Idiopathic Intracranial Hypertension on the Optic Nerves.Neuro-ophthalmology (Aeolus Press) · 2020Review
- Clinico-radiological correlation of magnetic resonance imaging findings in patients with idiopathic intracranial hypertension.Neuroradiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElevation of intracranial pressure in idiopathic intracranial hypertension induces an edema of the prelaminar section of the optic nerve (papilledema). Beside the commonly observed optic nerve sheath distention, information on a potential pathology of the retrolaminar section of the optic nerve and the short-term effect of normalization of intracranial pressure on these abnormalities remains scarce.
methodsIn this exploratory study 8 patients diagnosed with idiopathic intracranial hypertension underwent a MRI scan (T2 mapping) as well as a diffusion tensor imaging analysis (fractional anisotropy and mean diffusivity). In addition, the clinical presentation of headache and its accompanying symptoms were assessed. Intracranial pressure was then normalized by lumbar puncture and the initial parameters (MRI and clinical features) were re-assessed within 26 h.
resultsAfter normalization of CSF pressure, the morphometric MRI scans of the optic nerve and optic nerve sheath remained unchanged. In the diffusion tensor imaging, the fractional anisotropy value was reduced suggesting a tissue decompression of the optic nerve after lumbar puncture. In line with these finding, headache and most of the accompanying symptoms also improved or remitted within that short time frame.
conclusionThe findings support the hypothesis that the elevation of intracranial pressure induces a microstructural compression of the optic nerve impairing axoplasmic flow and thereby causing the prelaminar papilledema. The microstructural compression of the optic nerve as well as the clinical symptoms improve within hours of normalization of intracranial pressure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.