ArticleBMC anesthesiology2019
Impact of hypophosphatemia on outcome of patients in intensive care unit: a retrospective cohort study.
Article in BMC anesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05682846 (Impact of Serum Phosphorus Level Optimization on Weaning From Mechanical Ventilation in Adult ICU Patients), which is not on this map. Cited by 46 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Serum Phosphorus Level Optimization on Weaning From Mechanical Ventilation in Adult ICU Patients
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between blood phosphorus level and clinical outcomes in critically ill patients: A systematic review and meta-analysis.JPEN. Journal of parenteral and enteral nutrition · 2026Pooled it
- Postoperative Hypophosphatemia as a Prognostic Factor for Postoperative Pancreatic Fistula: A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Hypophosphatemia in Coronavirus Disease 2019 (COVID-19), Complications, and Considerations: A Systematic Review.BioMed research international · 2022Pooled it
- Early postoperative hypophosphatemia is an independent predictor of ileus after transforaminal lumbar interbody fusion: a multicenter retrospective cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- The impact and predictive value of refeeding syndrome on the short-term prognosis of patients with severe stroke: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Supplementation of calcium, magnesium, phosphate, and potassium in critically ill patients: A multicenter cohort study.PloS one · 2026Article
- Hypophosphatemia-factors associated with its development and 90-day mortality effect: a prospective observational study.Frontiers in medicine · 2026Article
- [Chronic Critical Illness in Burns: Incidence and Risk Factors].Annals of burns and fire disasters · 2025Article
- Association between serum phosphate levels and 28-day mortality in patients with sepsis-associated liver injury: a cohort study.BMC infectious diseases · 2025Article
- Article
- Association between serum phosphate levels and length of hospital stay in infants with neonatal sepsis: a retrospective cohort study.BMC pediatrics · 2025Observational
- Correlation Between Hypophosphatemia and Hyperventilation in Critically Ill Patients: Causes, Clinical Manifestations, and Management Strategies.Biomedicines · 2025Review
- Hypophosphatemia in Intensive Care Unit Canine Patients: Occurrence and Association With Mortality and Duration of Hospitalization.Veterinary clinical pathology · 2025Article
- The spectrum of hypophosphatemia in internal medicine: lessons from a Greek population study.Journal of endocrinological investigation · 2025Article
- Review
- Electrolyte disorders in the critically ill: a retrospective analysis.Scientific reports · 2025Article
- Acid-base and electrolyte changes in dogs after packed red blood cell transfusion.Veterinary clinical pathology · 2024Article
- Hypophosphataemia in Critical Illness: A Narrative Review.Journal of clinical medicine · 2024Review
- Observational
- Contributing factors to hypophosphatemia development in critically Ill ventilated patients: a retrospective cohort study.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypophosphatemia generally occurs in Intensive Care Units (ICUs), but its impact is often ignored. The aim of this study was to investigate whether hypophosphatemia can be a risk factor for ICU 28-day mortality.
methodsA single-center retrospective cohort study was conducted by collecting data from 1073 patients admitted to general ICU and then presented to the Sixth Affiliated Hospital, Sun Yat-sen University (Guangzhou City, Guangdong Province, China) from 1 January 2016 to 31 December 2017. The patients were divided into a normal control group (serum phosphate levels 0.80-1.60 mmol/L) and a hypophosphatemia group (serum phosphate levels < 0.80 mmol/L), based on the concentration of phosphorus at the time of ICU admission. The association between phosphate levels and ICU 28-day mortality was evaluated by binary logistic regression analysis. Multivariate logistic regression was employed to predict the ICU 28-day mortality.
resultsThe cohort included 946 patients with a median phosphate concentration of 0.77 mmol/L (interquartile range 0.55-1.03 mmol/L). Patients with hypophosphatemia had a higher ICU 28-day mortality than the normal control group (33.3% vs 24.0%, P < 0.05). Patients with hypophosphatemia had a longer ICU and hospital stays, and prolonged duration of mechanical ventilation (all P < 0.05). Hypophosphatemia was an independent risk factor for ICU 28-day mortality (adjusted OR = 1.5, 95% CI = 1.1-2.1, P = 0.01) in the multivariate logistic regression analysis.
conclusionsHypophosphatemia at admission is an independent risk factor for 28-day mortality in general ICU patients.
trial registrationThe medical study was approved by the Institutional Ethics Committee of the Six Affiliated Hospital, Sun Yat-sen University (Approval number: 2017ZSLYEC-110). No consent was given as the data were analyzed anonymously.
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