Evidence map›Paper›PMID 31122150›Full record

ArticleEpigenetics2019

Epigenome-wide effects of vitamin D on asthma bronchial epithelial cells.

Nadia Boutaoui, Sandeep Puranik, Rong Zhang, Ting Wang, Daniel H Hui, John Brehm, Erick Forno, Wei Chen, Juan C Celedón

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Nadia Boutaouia Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh , PA , USA.
Sandeep Puranika Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh , PA , USA.ORCID 0000-0002-8771-3593
Rong Zhanga Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh , PA , USA.
Ting Wangc Fred Hutchinson Cancer Research Center , Seattle , WA , USA.ORCID 0000-0003-4712-6658
Daniel H Huid Brigham and Women's Hospital, Harvard Medical School, Broad Institute , Boston , MA , USA.
John Brehme Division of Pulmonary and Critical Care Medicine, University of Pittsburgh Medical Center- St. Margret's Hospital, University of Pittsburgh , Pittsburgh , PA , USA.
Erick Fornoa Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh , PA , USA.ORCID 0000-0001-6497-9885
Wei Chena Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh , PA , USA.
Juan C Celedóna Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh , PA , USA.ORCID 0000-0002-6139-5320
University of Pittsburgh · USBroad Institute · USFred Hutch Cancer Center · USUniversity of Pittsburgh Medical Center · US

Funding

Epigenetic Variation and Childhood Asthma in Puerto RicansR01HL117191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2013 to 2020
$5.8M
Vitamin D to Prevent Severe Asthma Exacerbations in High-Risk Children - CCCU01HL119952 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2015 to 2018
$2.9M
Exposure to violence, epigenetic variation, and asthma in Puerto Rican childrenR01MD011764 · NIMHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2017 to 2020
$1.3M
Obesity and Asthma Subphenotypes and Underlying Genetic and Genomic PathwaysK08HL125666 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORNO, ERICK · 2015 to 2018
$589k
NHLBI NIH HHS K08 HL125666NHLBI NIH HHS R01 HL117191NHLBI NIH HHS U01 HL119952NIMHD NIH HHS R01 MD011764
6 · The paper itself

Abstract

Vitamin D is a nutrient and a hormone with multiple effects on immune regulation and respiratory viral infections, which can worsen asthma and lead to severe asthma exacerbations. We set up a complete experimental and analytical pipeline for ATAC-Seq and RNA-Seq to study genome-wide epigenetic changes in human bronchial epithelial cells of asthmatic subjects, following treatment of these cells with calcitriol (vitamin D3) and Poly (I:C)(a viral analogue). This approach led to the identification of biologically plausible candidate genes for viral infections and asthma, such as DUSP10 and SLC44A1.

Indexed as

Antigens, CDAsthmaBronchiCells, CulturedDual-Specificity PhosphatasesEpigenesis, GeneticEpigenomicsEpithelial CellsGene Expression RegulationHumansMitogen-Activated Protein Kinase PhosphatasesOrganic Cation Transport ProteinsPoly I-CSequence Analysis, RNAVitamin DAntigens, CDDual-Specificity PhosphatasesDUSP10 protein, humanMitogen-Activated Protein Kinase PhosphatasesOrganic Cation Transport ProteinsPoly I-CSLC44A1 protein, humanVitamin DasthmaATAC-SeqRNA-SeqVitamin D

Identifiers

PMID31122150
PMCPMC6691985
OpenAlexW2944942548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.