Evidence map›Paper›PMID 31122134›Full record

ArticleGut microbes2020

In search of stool donors: a multicenter study of prior knowledge, perceptions, motivators, and deterrents among potential donors for fecal microbiota transplantation.

Breanna McSweeney, Jessica R Allegretti, Monika Fischer, Huiping Xu, Karen J Goodman, Tanya Monaghan, Carmen McLeod, Benjamin H Mullish, Elaine O Petrof, Emmalee L Phelps and 7 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  12. The Next Generation Fecal Microbiota Transplantation: To Transplant Bacteria or Virome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
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  18. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 3 countries.

Breanna McSweeneyDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Jessica R AllegrettiDivision of Gastroenterology, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Monika FischerDivision of Gastroenterology and Hepatology, Indiana University, Indianapolis, IN, USA.
Huiping XuDepartment of Biostatistics, The Richard M. Fairbanks School of Public Health and School of Medicine, Indiana University, Indianapolis, IN, USA.
Karen J GoodmanDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-3790-3217
Tanya MonaghanNIHR Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK.
Carmen McLeodNottingham Synthetic Biology Research Centre, School of Life Sciences, University of Nottingham, Nottingham, UK.ORCID 0000-0003-2005-3778
Benjamin H MullishDivision of Integrative Systems Medicine and Digestive Disease, Faculty of Medicine, Imperial College London, London, UK.ORCID 0000-0001-6300-3100
Elaine O PetrofDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Emmalee L PhelpsDivision of Gastroenterology and Hepatology, Indiana University, Indianapolis, IN, USA.
Roxana ChisDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Abby EdmisonDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Angela JubyDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Ralph Ennis-DavisDepartment of Medicine, Alberta Health Services, Edmonton, Alberta, Canada.
Brandi RoachZeidler Ledcor Center, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.
Karen WongZeidler Ledcor Center, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.
Dina KaoZeidler Ledcor Center, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-6096-0586
University of Alberta · CAIndiana University – Purdue University Indianapolis · USQueen's University · CAAlberta Health Services · CABrigham and Women's Hospital · USImperial College London · GBIndiana University Indianapolis · USNottingham University Hospitals NHS Trust · GBUniversity of Nottingham · GB

Funding

Medical Research Council MR/R000875/1
6 · The paper itself

Abstract

Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridioides difficile infection. Stool donors are essential, but difficult to recruit and retain. We aimed to identify factors influencing willingness to donate stool. This multi-center study with a 32-item questionnaire targeted young adults and health care workers via social media and university email lists in Edmonton and Kingston, Canada; London and Nottingham, England; and Indianapolis and Boston, USA. Items included baseline demographics and FMT knowledge and perception. Investigated motivators and deterrents included economic compensation, screening process, time commitment, and stool donation logistics. Logistic regression and linear regression models estimated associations of study variables with self-assessed willingness to donate stool. 802 respondents completed our questionnaire: 387 (48.3%) age 21-30 years, 573 (71.4%) female, 323 (40%) health care workers. Country of residence, age and occupation were not associated with willingness to donate stool. Factors increasing willingness to donate were: already a blood donor (OR 1.64), male, altruism, economic benefit, knowledge of how FMT can help patients (OR 1.32), and positive attitudes towards FMT (OR 1.39). Factors decreasing willingness to donate were: stool collection unpleasant (OR 0.92), screening process invasive (OR 0.92), higher stool donation frequency, negative social perception of stool, and logistics of collection/transporting feces. We conclude that 1) blood donors and males are more willing to consider stool donation; 2) altruism, economic compensation, and positive feedback are motivators; and 3) screening process, high donation frequency, logistics of collection/transporting feces, lack of public awareness, and negative social perception are deterrents. Considering these variables could maximize donor recruitment and retention.

Indexed as

CanadaClostridium InfectionsFecal Microbiota TransplantationFecesFemaleHumansMaleMiddle AgedSurveys and QuestionnairesTissue DonorsYoung AdultClostridioides difficile infection (CDI)Fecal microbiota transplantation (FMT)fecal transplant donorsrecurrent Clostridioides difficile infection (RCDI)stool donors

Identifiers

PMID31122134
PMCPMC6973337
OpenAlexW2945760870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.