Evidence map›Paper›PMID 31122127›Full record

ArticleCell cycle (Georgetown, Tex.)2019

Long noncoding RNA MAGI1-IT1 promoted invasion and metastasis of epithelial ovarian cancer via the miR-200a/ZEB axis.

Hao Gao, Xiaofeng Li, Guangxi Zhan, Yong Zhu, Jing Yu, Jiapo Wang, Li Li, Weimin Wu, Na Liu, Xiaoqing Guo

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hao Gaoa Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital , Tongji University School of Medicine , Shanghai , China.
Xiaofeng Lia Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital , Tongji University School of Medicine , Shanghai , China.
Guangxi Zhana Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital , Tongji University School of Medicine , Shanghai , China.
Yong Zhub Department of Obstetrics and Gynecology , Central Theater of the Chinese PLA , Wuhan , China.
Jing Yuc Department of Pathology, Shanghai First Maternity and Infant Hospital , Tongji University School of Medicine , Shanghai , China.
Jiapo Wanga Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital , Tongji University School of Medicine , Shanghai , China.
Li Lia Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital , Tongji University School of Medicine , Shanghai , China.
Weimin Wua Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital , Tongji University School of Medicine , Shanghai , China.
Na Liua Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital , Tongji University School of Medicine , Shanghai , China.
Xiaoqing Guoa Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital , Tongji University School of Medicine , Shanghai , China.
Shanghai First Maternity and Infant Hospital · CNCentral Hospital of Wuhan · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, and its vulnerability to metastasis contributes to the poor outcomes of EOC patients. Long noncoding RNAs (lncRNAs) were verified to play a pivotal role in EOC metastasis. However, the potential role of lncRNA membrane-associated guanylate kinase inverted 1 (MAGI1) intronic transcript (MAGI1-IT1) in EOC is largely unknown. In this study, the function and mechanisms of MAGI1-IT1 in EOC metastasis were explored profoundly. First, MAGI1-IT1 expression was found to be significantly decreased in overexpressing miR-200a EOC cells. Second, MAGI1-IT1 expression was remarkably increased in metastatic EOC tissues, and high MAGI1-IT1 was dramatically associated with EOC FIGO III-IV stage; in addition, MAGI1-IT1 might be related to EOC dissemination via epithelial-mesenchymal transition (EMT). Next, a series of gain- and loss-of-function assays verified that, although MAGI1-IT1 has no significant role in EOC proliferation and subcutaneous xenograft growth, the upregulation of MAGI1-IT1 can remarkably facilitate EOC EMT phenotype, cells migration and invasion ability and intraperitoneal metastasis in nude mice, while downregulation of MAGI1-IT1 led to the opposite effect

Indexed as

Signal TransductionAnimalsBase SequenceCarcinoma, Ovarian EpithelialCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMice, NudeMicroRNAsMiddle AgedNeoplasm InvasivenessNeoplasm MetastasisMicroRNAsMIRN200 microRNA, humanRNA, Long NoncodingZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1Epithelial ovarian cancerinvasion and metastasisMAGI1-IT1miR-200aZEB1 and ZEB2

Identifiers

PMID31122127
PMCPMC6592227
OpenAlexW2946463713

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.