Evidence map›Paper›PMID 31121065›Full record

ArticleJournal of internal medicine2019

Predictive value of low testosterone concentrations regarding coronary heart disease and mortality in men and women - evidence from the FINRISK97 study.

T Zeller, S Appelbaum, K Kuulasmaa, T Palosaari, S Blankenberg, P Jousilahti, V Salomaa, M Karakas

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Journal of internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Testosterone replacement therapy and cardiovascular disease.International journal of impotence research · 2022
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

T ZellerClinic of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.ORCID 0000-0003-3379-2641
S AppelbaumClinic of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
K KuulasmaaNational Institute for Health and Welfare, Helsinki, Finland.
T PalosaariNational Institute for Health and Welfare, Helsinki, Finland.
S BlankenbergClinic of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
P JousilahtiNational Institute for Health and Welfare, Helsinki, Finland.
V SalomaaNational Institute for Health and Welfare, Helsinki, Finland.
M KarakasClinic of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Finnish Institute for Health and Welfare · FIUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe relevance of low testosterone concentrations for incident coronary heart disease (CHD) and mortality has been discussed in various studies. Here, we evaluate the predictive value of low baseline testosterone levels in a large population-based cohort.

methodsWe measured the serum levels of testosterone in 7671 subjects (3710 male, 3961 female) of the population-based FINRISK97 study.

resultsThe median follow-up (FU) was 13.8 years. During the FU, a total of 779 deaths from any cause, and 395 incident CHD events were recorded. The age-adjusted baseline testosterone levels were similar in subjects suffering incident events during FU and those without incident events during FU (men: 15.80 vs. 17.01 nmol L

conclusionsLow levels of testosterone are not predictive regarding future CHD or mortality - neither in men, nor in women.

Indexed as

AdultAgedBiomarkersCoronary DiseaseFemaleFinlandHumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesTestosteroneBiomarkersTestosteronebiomarkercoronary heart diseasemortalityprognosistestosterone

Identifiers

PMID31121065
PMCPMC6851597
OpenAlexW2945355703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.