ArticleJournal of neuroendocrinology2019
Identification of mineralocorticoid receptor target genes in the mouse hippocampus.
Article in Journal of neuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- 11β-HSD2 buffers fetal glucocorticoid exposure inducingPNAS nexus · 2026Article
- Region-specific regulation of glucocorticoid and mineralocorticoid receptor signaling in a mouse model of oral contraceptive exposure.bioRxiv : the preprint server for biology · 2026Article
- Mineralocorticoid receptor knockout alters hippocampal CA2 neurons to become like those in CA1.Communications biology · 2025Article
- The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated manner.The Journal of endocrinology · 2025Article
- Sex-related differences and associated transcriptional signatures in the brain ventricular system and cerebrospinal fluid development in full-term neonates.Biology of sex differences · 2025Article
- Control of sodium appetite by hindbrain aldosterone-sensitive neurons.Molecular and cellular endocrinology · 2024Review
- The role of the mineralocorticoid receptor in steroidinduced cytotoxicity in pediatric acute lymphoblastic leukemia.Haematologica · 2024Article
- Coping with the multifaceted and multifunctional role of cortisol in the brain.Neuroscience applied · 2024Review
- Do Corticosteroid Receptor mRNA Levels Predict the Expression of Their Target Genes?Journal of the Endocrine Society · 2022Article
- Brain mineralocorticoid and glucocorticoid receptor balance in neuroendocrine regulation and stress-related psychiatric etiopathologies.Current opinion in endocrine and metabolic research · 2022Review
- Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted therapy.Neurobiology of stress · 2022Article
- Gene expression changes in the brain of a Cushing's syndrome mouse model.Journal of neuroendocrinology · 2022Article
- Mineralocorticoid receptor status in the human brain after dexamethasone treatment: a single case study.Endocrine connections · 2022Article
- Cell type specificity of glucocorticoid signaling in the adult mouse hippocampus.Journal of neuroendocrinology · 2022Article
- Dexamethasone-associated metabolic effects in male mice are partially caused by depletion of endogenous corticosterone.Frontiers in endocrinology · 2022Article
- Article
- Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5.Cell reports · 2021Article
- Experience and activity-dependent control of glucocorticoid receptors during the stress response in large-scale brain networks.Stress (Amsterdam, Netherlands) · 2021Article
- The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders.Nature communications · 2020Observational
- The selective glucocorticoid receptor antagonist CORT125281 has tissue-specific activity.The Journal of endocrinology · 2020Article
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Authors and funding
13 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) respond to the same glucocorticoid hormones but can have differential effects on cellular function. Several lines of evidence suggest that MR-specific target genes must exist and might underlie the distinct effects of the receptors. The present study aimed to identify MR-specific target genes in the hippocampus, a brain region where MR and GR are co-localised and play a role in the stress response. Using genome-wide binding of both receptor types, we previously identified MR-specific, MR-GR overlapping and GR-specific putative target genes. We now report altered gene expression levels of such genes in the hippocampus of forebrain MR knockout (fbMRKO) mice, killed at the time of their endogenous corticosterone peak. Of those genes associated with MR-specific binding, the most robust effect was a 50% reduction in Jun dimerization protein 2 (Jdp2) mRNA levels in fbMRKO mice. Down-regulation was also observed for the MR-specific Nitric oxide synthase 1 adaptor protein (Nos1ap) and Suv3 like RNA helicase (Supv3 l1). Interestingly, the classical glucocorticoid target gene FK506 binding protein 5 (Fkbp5), which is associated with MR and GR chromatin binding, was expressed at substantially lower levels in fbMRKO mice. Subsequently, hippocampal Jdp2 was confirmed to be up-regulated in a restraint stress model, posing Jdp2 as a bona fide MR target that is also responsive in an acute stress condition. Thus, we show that MR-selective DNA binding can reveal functional regulation of genes and further identify distinct MR-specific effector pathways.
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