ArticlePloS one2019
Analysis of environmental risk factors for chronic obstructive pulmonary disease exacerbation: A case-crossover study (2004-2013).
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic risk factors for moderate-to-severe exacerbations in patients with chronic obstructive pulmonary disease: a systematic literature review.Respiratory research · 2022Pooled it
- Development of a nomogram to predict 30-day mortality in patients with chronic obstructive pulmonary disease complicated by sepsis: insights from the Medical Information Mart for Intensive Care (MIMIC-IV) database.Journal of thoracic disease · 2025Article
- Sex Differences in Chronic Obstructive Pulmonary Disease: Implications for Pathogenesis, Diagnosis, and Treatment.International journal of molecular sciences · 2025Review
- Global, Regional, and National Burden of COPD Among Women from 1990 to 2021 and Projections to 2050: A Systematic Analysis for the Global Burden of Disease Study 2021.Annals of global health · 2025Article
- Global climate change: The dangers of heatwaves for chronic obstructive pulmonary disease patients cannot be ignored.Journal of global health · 2024Article
- Exploring the Relationship between Acute Coronary Syndrome, Lower Respiratory Tract Infections, and Atmospheric Pollution.Journal of clinical medicine · 2024Article
- Prediction and stratification of longitudinal risk for chronic obstructive pulmonary disease across smoking behaviors.Nature communications · 2023Article
- Pulmonary, inflammatory, and oxidative effects of indoor nitrogen dioxide in patients with COPD.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- Trends in hospital admissions for chronic obstructive pulmonary disease over 16 years in Canada.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Article
- Association between the temperature difference and acute exacerbations of chronic obstructive pulmonary disease: A time-series analysis with 143,318 hospital admissions in Beijing, China.Frontiers in public health · 2023Article
- HealMA: a model-driven framework for automatic generation of IoT-based Android health monitoring applications.Automated software engineering · 2022Article
- Exposure Response Relationship of Acute Effects of Air Pollution on Respiratory Diseases - China, 2013-2018.China CDC weekly · 2021Article
- Environmental risk factor assessment for major respiratory disorders in metropolitan cities of India using VIIRS Suomi Aerosol data and Google Trends.Environmental sustainability (Singapore) · 2021Article
- Air pollution and chronic obstructive pulmonary disease.Chronic diseases and translational medicine · 2020Review
- Short-term effect of particular matter and sulfur dioxide exposure on asthma and/or chronic obstructive pulmonary disease hospital admissions in Center of Anatolia.Environmental monitoring and assessment · 2020Article
- Tiotropium in chronic obstructive pulmonary disease - a review of clinical development.Respiratory research · 2020Review
- Rationale, Study Design, and Cohort Characteristics for the Markers for Environmental Exposures (MEE) Study.International journal of environmental research and public health · 2020Article
- Effects of Ambient Temperature on Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Results from a Time-Series Analysis of 143318 Hospitalizations.International journal of chronic obstructive pulmonary disease · 2020Article
- Risk Factors for Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Industrial Regions of China: A Multicenter Cross-Sectional Study.International journal of chronic obstructive pulmonary disease · 2020Article
- The Effects and Safety of Chinese Oral Herbal Paste on Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Evidence-based complementary and alternative medicine : eCAM · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe aim to assess if air pollution levels and climatological factors are associated with hospital admissions for exacerbation of chronic obstructive pulmonary disease (COPD) in Spain from 2004 to 2013.
methodsWe conducted a retrospective study. Information on pollution level and climatological factors were obtained from the Spanish Meteorological Agency and hospitalizations from the Spanish hospital discharge database. A case-crossover design was used to identify factors associated with hospitalizations and in hospital mortality. Postal codes were used to assign climatic and pollutant factors to each patient.
resultsWe detected 162,338 hospital admissions for COPD exacerbation. When seasonal effects were evaluated we observed that hospital admissions and mortality were more frequent in autumn and winter. In addition, we found significant associations of temperature, humidity, ozone (O3), carbon monoxide (CO), particulate matter up to 10 μm in size (PM10) and nitrogen dioxide (NO2) with hospital admissions. Lower temperatures at admission with COPD exacerbation versus 1, 1.5, 2 and 3 weeks prior to hospital admission for COPD exacerbation, were associated with a higher probability of dying in the hospital. Other environmental factors that were related to in-hospital mortality were NO2, O3, PM10 and CO.
conclusionsEpidemiology of hospital admissions by COPD exacerbation was negatively affected by colder climatological factors (seasonality and absolute temperature) and short-term exposure to major air pollution (NO2, O3, CO and PM10).
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