Evidence map›Paper›PMID 31120894›Full record

ArticlePLoS genetics2019

De novo gene birth.

Stephen Branden Van Oss, Anne-Ruxandra Carvunis

Abstract read
In one paragraph

Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

186 citing papers in PubMed.

  1. Review
  2. DetectNAR genomics and bioinformatics · 2026
    Article
  3. The diverse functions of viral microproteins.bioRxiv : the preprint server for biology · 2026
    Article
  4. Emergence Biases in Molecular Evolution.Genome biology and evolution · 2026
    Review
  5. Article
  6. Article
  7. High-resolution global recombination mapping inbioRxiv : the preprint server for biology · 2026
    Article
  8. Descent from a common ancestor restricts exploration of protein sequence space.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Imported, not invented, genes prevail amongProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Origin of class B J-domain proteins involved in amyloid transactions.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. Impact of GC content on de novo gene birth.Nature communications · 2026
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stephen Branden Van OssDepartment of Computational and Systems Biology, Pittsburgh Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.ORCID 0000-0002-2933-7083
Anne-Ruxandra CarvunisDepartment of Computational and Systems Biology, Pittsburgh Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.ORCID 0000-0002-6474-6413

Funding

Deciphering the mechanisms and dynamics of proto-gene evolutionR00GM108865 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARVUNIS, ANNE-RUXANDRA · 2017 to 2019
$747k
Investigating mechanisms of de novo gene birth in Saccharomyces cerevisiaeF32GM129929 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN OSS, S. BRANDEN · 2018 to 2020
$185k
NIGMS NIH HHS F32 GM129929NIGMS NIH HHS R00 GM108865
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Evolution, MolecularAnimalsDNA Polymerase IIGenesHumansDNA Polymerase II

Identifiers

PMID31120894
PMCPMC6542195

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.