ArticleeLife2019
Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Alpha-thalassaemia: from regional burden to global priority.The Lancet regional health. Southeast Asia · 2026Article
- The epidemiology of thalassaemia syndromes in Southeast Asia.The Lancet regional health. Southeast Asia · 2026Review
- Molecular profiling of thalassemia in Southeastern Romania.Journal of hematopathology · 2026Article
- Nanoplate Digital PCR for Identification of αInternational journal of molecular sciences · 2026Article
- Assessment of a High-Resolution HPLC System to Quantify HbE for αAnnals of laboratory medicine · 2026Article
- Establishment of an immortalized erythroid model for Hb Bart's hydrops fetalis with homozygous αScientific reports · 2026Article
- Pregnancy induced hypertension and mirror syndrome associated with fetal hemoglobin Bart's disease in Thailand: a retrospective cohort study.The Lancet regional health. Southeast Asia · 2026Article
- Fetal Cardiovascular Profile Score (CVPs) in Fetal Anemia, Using Fetal Hemoglobin Bart's Disease at Mid-Pregnancy as a Study Model.Diagnostics (Basel, Switzerland) · 2025Article
- HbA1c levels in hemoglobin H disease.Biochemistry and biophysics reports · 2025Article
- Clinical Spectrum and Genotypes of Children with Hemoglobin H in Northeastern Thailand.Mediterranean journal of hematology and infectious diseases · 2025Article
- Article
- Erythropoiesis and Gene Expression Analysis in Erythroid Progenitor Cells Derived from Patients with Hemoglobin H/Constant Spring Disease.International journal of molecular sciences · 2024Article
- Article
- Hematological Profile of Hb Adana Among High School Students in Northeast Peninsular Malaysia.Cureus · 2024Article
- Revisiting and updating molecular epidemiology of α-thalassemia mutations in Thailand using MLPA and new multiplex gap-PCR for nine α-thalassemia deletion.Scientific reports · 2023Article
- Article
- Consensus statement for the perinatal management of patients with α thalassemia major.Blood advances · 2021Article
- Identification of optimal thalassemia screening strategies for migrant populations in Thailand using a qualitative approach.BMC public health · 2021Article
- Feasibility of and barriers to thalassemia screening in migrant populations: a cross-sectional study of Myanmar and Cambodian migrants in Thailand.BMC public health · 2021Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Severe forms of α-thalassaemia, haemoglobin H disease and haemoglobin Bart's hydrops fetalis, are an important public health concern in Southeast Asia. Yet information on the prevalence, genetic diversity and health burden of α-thalassaemia in the region remains limited. We compiled a geodatabase of α-thalassaemia prevalence and genetic diversity surveys and, using geostatistical modelling methods, generated the first continuous maps of α-thalassaemia mutations in Thailand and sub-national estimates of the number of newborns with severe forms in 2020. We also summarised the current evidence-base for α-thalassaemia prevalence and diversity for the region. We estimate that 3595 (95% credible interval 1,717-6,199) newborns will be born with severe α-thalassaemia in Thailand in 2020, which is considerably higher than previous estimates. Accurate, fine-scale epidemiological data are necessary to guide sustainable national and regional health policies for α-thalassaemia management. Our maps and newborn estimates are an important first step towards this aim. Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).
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