Evidence map›Paper›PMID 31120356›Full record

ArticleJournal of aerosol medicine and pulmonary drug delivery2019

The Cystic Fibrosis-Like Airway Surface Layer Is not a Significant Barrier for Delivery of Eluforsen to Airway Epithelial Cells.

Vera Brinks, Katarzyna Lipinska, Miranda de Jager, Wouter Beumer, Brian Button, Alessandra Livraghi-Butrico, Noreen Henig, Bianca Matthee

Open access · greenAbstract read
In one paragraph

Article in Journal of aerosol medicine and pulmonary drug delivery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Systematic deletion of symmetricalNAR molecular medicine · 2024
    Article
  5. Review
  6. Oligonucleotide-based therapies for cystic fibrosis.Current opinion in pharmacology · 2022
    Review
  7. Review
  8. Open reading frame correction using splice-switching antisense oligonucleotides for the treatment of cystic fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
  10. A comparison of three mucus-secreting airway cell lines (Calu-3, SPOC1 and UNCN3T) for use as biopharmaceutical models of the nose and lung.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2021
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Vera BrinksProQR Therapeutics, Leiden, The Netherlands.
Katarzyna LipinskaProQR Therapeutics, Leiden, The Netherlands.
Miranda de JagerProQR Therapeutics, Leiden, The Netherlands.
Wouter BeumerProQR Therapeutics, Leiden, The Netherlands.
Brian ButtonDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Alessandra Livraghi-ButricoMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Noreen HenigProQR Therapeutics, Leiden, The Netherlands.
Bianca MattheeProQR Therapeutics, Leiden, The Netherlands.
ProQR Therapeutics (Netherlands) · NLUniversity of North Carolina at Chapel Hill · US

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Richard Charles Boucher, Martina Gentzsch · 2004 to 2026
$26.5M
The Biophysics of Mucus Hydration and Adhesion/CohesionP01HL108808 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEDEN, DAVID B. · 2012 to 2021
$23.9M
UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI David M. Bedwell · 2007 to 2026
$23.0M
The Mucus Transport Apparatus: Why Two Layers?P50HL084934 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2006 to 2010
$15.6M
THE BIOLOGY OF MUCUS AND MUCUS PLAQUES ON CF AIRWAYSP50HL060280 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHUA, MICHAEL · 1998 to 2007
$14.0M
Purinergic Control of CFTR-ENaC Interactions in Alveolar EpitheliaP01HL110873 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2012 to 2016
$10.7M
Translational Program in CFTR-Related Airway DiseasesR35HL135816 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROWE, STEVEN MARK · 2017 to 2022
$6.3M
Synthesis of Effective and Safe Mucolytics for Pulmonary DiseaseUH3HL123645 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2016 to 2018
$4.6M
UAB Center for Clinical and Translational Science (CCTS)U54TR001005 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2014 to 2014
$4.6M
The role of mucus and pulmonary surface interactions in lung defenseR01HL125280 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUTTON, BRIAN M · 2015 to 2023
$3.1M
Synthesis of Effective and Safe Mucolytics for Pulmonary DiseaseUH2HL123645 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2014 to 2015
$2.9M
Mucus Adhesion to Epithelial Cells and its Mobilization in COPD and CFP50HL107168 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES, DOERSCHUK, CLAIRE M · 2011 to 2012
$885k
NCATS NIH HHS U54 TR001005NHLBI NIH HHS P01 HL108808NHLBI NIH HHS P01 HL110873NHLBI NIH HHS P50 HL060280NHLBI NIH HHS P50 HL084934NHLBI NIH HHS P50 HL107168NHLBI NIH HHS R01 HL125280NHLBI NIH HHS R35 HL135816NHLBI NIH HHS UH2 HL123645NHLBI NIH HHS UH3 HL123645NIDDK NIH HHS P30 DK065988NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Administration, InhalationAnimalsBiofilmsCells, CulturedCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsFemaleHumansLungMaleMiceMice, Inbred C57BLOligonucleotidesOligonucleotides, AntisensePseudomonas aeruginosaCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatoreluforsenOligonucleotidesOligonucleotides, Antisenseairway surface layercystic fibrosisdeliverydeltaF508eluforsenQR-010

Identifiers

PMID31120356
PMCPMC6781260
OpenAlexW2945301211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.