Evidence map›Paper›PMID 31120251›Full record

ArticleJournal of natural products2019

Caspase-Dependent Apoptosis in Prostate Cancer Cells and Zebrafish by Corchorusoside C from Streptocaulon juventas.

Gerardo D Anaya-Eugenio, Ermias Mekuria Addo, Nathan Ezzone, Joshua M Henkin, Tran Ngoc Ninh, Yulin Ren, Djaja D Soejarto, A Douglas Kinghorn, Esperanza J Carcache de Blanco

Open access · greenAbstract read
In one paragraph

Article in Journal of natural products, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Bioactive compounds isolated from the bark ofPhytochemistry letters · 2024
    Article
  3. Review
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  14. NaJournal of natural products · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Gerardo D Anaya-Eugenio
Ermias Mekuria Addo
Nathan Ezzone
Joshua M HenkinDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , University of Illinois at Chicago , Chicago , Illinois 60612 , United States.
Tran Ngoc NinhInstitute of Ecology and Biological Resources , Vietnam Academy of Science and Technology , Hoang Quoc Viet, Cau Giay , Hanoi Vietnam.
Yulin Ren
Djaja D SoejartoDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , University of Illinois at Chicago , Chicago , Illinois 60612 , United States.
A Douglas KinghornORCID 0000-0002-6647-8707
Esperanza J Carcache de BlancoORCID 0000-0002-9519-3292
The Ohio State University · USUniversity of Illinois Chicago · USVietnam Academy of Science and Technology · VN

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JAMES R FUCHS · 2007 to 2026
$27.2M
NCI NIH HHS P01 CA125066
6 · The paper itself

Abstract

Corchorusoside C (1), isolated from Streptocaulon juventas collected in Vietnam, was found to be nontoxic in a zebrafish ( Danio rerio) model and to induce cytotoxicity in several cancer cell lines with notable selective activity against prostate DU-145 cancer cells (IC

Indexed as

AnimalsAntineoplastic Agents, PhytogenicApocynaceaeApoptosisCaspasesCell Line, TumorHumansI-kappa B KinaseMaleMolecular StructurePoly (ADP-Ribose) Polymerase-1ProstateProstatic NeoplasmsProto-Oncogene Proteins c-bcl-2PyransVietnamAntineoplastic Agents, PhytogenicBCL2 protein, humanCaspasesI-kappa B KinasePARP1 protein, humanPoly (ADP-Ribose) Polymerase-1Proto-Oncogene Proteins c-bcl-2Pyrans

Identifiers

PMID31120251
PMCPMC6615048
OpenAlexW2945757124

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.