Evidence map›Paper›PMID 31119977›Full record

ArticleGut microbes2020

Regulation of interferon signaling in response to gut microbes by autophagy.

Patricia K Martin, Ken Cadwell

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Patricia K MartinKimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY, USA.
Ken CadwellKimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY, USA.
New York University · US

Funding

Diabetes, Digestive, and Kidney Diseases Extramural ResearchR01DK093668 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2011 to 2026
$7.3M
Redefining the role of autophagy in bacterial diseaseR01AI121244 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2017 to 2026
$5.6M
The role of autophagy gene Atg16L1 in allogeneic hematopoietic stem cell transplantation - Resubmission - 1R01HL123340 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA, VAN DEN BRINK, MARCEL R M · 2015 to 2022
$5.2M
Role of Nod2 in preventing intestinal disease downstream of microbial imbalancesR01DK103788 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA, LOKE, PNG · 2015 to 2017
$1.3M
The Role of Autophagy During in vivo Salmonella InfectionF31DK111139 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARTIN, PATRICIA · 2016 to 2017
$88k
Howard Hughes Medical InstituteNHLBI NIH HHS R01 HL123340NIAID NIH HHS R01 AI121244NIDDK NIH HHS F31 DK111139NIDDK NIH HHS R01 DK093668NIDDK NIH HHS R01 DK103788
6 · The paper itself

Abstract

The cellular degradative pathway of autophagy prevents unrestrained inflammatory signaling by removing intracellular microbes, damaged organelles, and other factors that trigger immune reactions. Consistent with this function, a common variant of the autophagy gene

Indexed as

AnimalsAutophagyAutophagy-Related ProteinsGastrointestinal MicrobiomeImmunity, InnateInflammatory Bowel DiseasesInterferon Type IIntestinal MucosaMiceSignal TransductionAtg16l1 protein, mouseAutophagy-Related ProteinsInterferon Type IATG16L1Autophagyinflammatory bowel diseaseinterferonmicrobiota

Identifiers

PMID31119977
PMCPMC6973319
OpenAlexW2945226178

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.