ArticleObesity (Silver Spring, Md.)2019
The FTO Gene and Measured Food Intake in 5- to 10-Year-Old Children Without Obesity.
Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Polygenic risk score for obesity and the quality, quantity, and timing of workplace food purchases: A secondary analysis from the ChooseWell 365 randomized trial.PLoS medicine · 2020Trial
- Associations Between FTO rs9939609 Genotype, Physical Activity, and Dietary Behaviors in Young Adults.Nutrients · 2026Article
- Association Between Industrialized Dietary Pattern and Cardiometabolic Risk Factors in Children With FTO RS9939609 Gene Polymorphism.Molecular nutrition & food research · 2025Article
- Risk of Fat Mass- and Obesity-Associated Gene-Dependent Obesogenic Programming by Formula Feeding Compared to Breastfeeding.Nutrients · 2024Review
- Impact of polygenic score for BMI on weight loss effectiveness and genome-wide association analysis.International journal of obesity (2005) · 2024Observational
- Article
- Genetic associations with neural reward responsivity to food cues in children.Frontiers in nutrition · 2024Article
- Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases.Genes & diseases · 2023Review
- Heightened sensitivity to high-calorie foods in children at risk for obesity: insights from behavior, neuroimaging, and genetics.Brain imaging and behavior · 2023Article
- Role of rs9939506 polymorphism of FTO gene in resistance to eating in male adolescents.BMC pediatrics · 2023Article
- Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged children.Scientific reports · 2023Article
- Genetic predisposition to macronutrient preference and workplace food choices.Molecular psychiatry · 2023Article
- Technologies, strategies, and cautions when deconvoluting genome-wide association signals: FTO in focus.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Review
- FTO and Anthropometrics: The Role of Modifiable Factors.Journal of functional morphology and kinesiology · 2022Review
- TheCurrent developments in nutrition · 2022Article
- The Families Improving Health Together (FIT) Program: Initial evaluation of retention and research in a multispecialty clinic for children with obesity.Obesity science & practice · 2021Article
- Extensive pleiotropism and allelic heterogeneity mediate metabolic effects ofScience (New York, N.Y.) · 2021Article
- Whole Genome Interpretation for a Family of Five.Frontiers in genetics · 2021Article
- Novel Targets in Glucose Homeostasis and Obesity-Lesson from Rare Mutations.Current diabetes reports · 2020Review
- The Impact ofNutrients · 2020Article
Corrections and comments
- Commented on by
Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveGenetic variation in the first intron of FTO (e.g., single-nucleotide polymorphism [SNP] rs9939609) is strongly associated with adiposity. This effect is thought to be mediated (at least in part) via increasing caloric intake, although the precise molecular genetic mechanisms are not fully understood. Prior pediatric studies of FTO have included youth with overweight and obesity; however, they have not informed whether a genotypic effect on ingestive behavior is present prior to obesity onset. Therefore, this study investigated the association between FTO and caloric intake in children aged 5 to 10 years without obesity (adiposity ≤ 95th percentile).
methodsA total of 122 children were genotyped for rs9939609 and ate ad libitum from a laboratory lunch buffet following a standardized breakfast. Linear regressions, adjusting for body mass, were used to examine the association between FTO "dose" (number of copies of SNP rs9939609) and intake variables.
resultsThere was a significant association between FTO and total intake. Each risk allele predicted an additional 64 calories, accounting for 3% of the variance. There were no associations between FTO and macronutrient preference, energy density, or diet variety. Results were influenced by race.
conclusionsResults corroborate and extend prior work by showing a dose-dependent effect on food intake in children without obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.