ArticleStatistics in medicine2019
Adjusted restricted mean survival times in observational studies.
Article in Statistics in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Continuous renal replacement therapy versus intermittent hemodialysis as first modality for renal replacement therapy in severe acute kidney injury: a secondary analysis of AKIKI and IDEAL-ICU studies.Critical care (London, England) · 2022Trial
- Outcome-Adaptive Lasso for Cox Proportional Hazards Model.Biometrical journal. Biometrische Zeitschrift · 2026Article
- Observational
- Impact of Transjugular Intrahepatic Portosystemic Shunt on Waitlist and Post-transplant Outcomes in Liver Transplant Candidates.Digestive diseases and sciences · 2026Article
- Neoadjuvant and adjuvant treatment for pancreatic ductal adenocarcinoma in patients over 80 years old based on a nationwide clinical database.Journal of gastroenterology · 2026Article
- Abbreviated dual antiplatelet therapy after percutaneous coronary intervention with drug coated balloons in acute coronary syndromes: insights from the SWEDEHEART registry.European heart journal. Cardiovascular pharmacotherapy · 2026Observational
- The hazards of using hazard ratios from proportional hazard models in indirect treatment comparisons.Research synthesis methods · 2026Article
- Real-World Effectiveness of Second-Line Therapies in Advanced Non-Small Cell Lung Cancer: Insights From Propensity-Weighted Comparative Analyses of Longitudinal EHR Data.Clinical lung cancer · 2026Article
- Utility of Restricted Mean Survival Time Analysis for Renal Replacement Therapy in Patients with Sepsis Associated Acute Kidney Injury: A Retrospective Study.International journal of general medicine · 2026Article
- FedECA: federated external control arms for causal inference with time-to-event data in distributed settings.Nature communications · 2025Article
- Sex Differences in Stroke Care and Outcomes: A National Stroke Registry Study.Journal of the American Heart Association · 2025Article
- Heart donation and transplant recipient survival outcomes from deceased organ donors managed in hospital-based vs independent donor care units.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
- Real-world efficacy of immune checkpoint inhibitors in PD-L1 negative non-small cell lung cancer: a multicenter retrospective study.Translational lung cancer research · 2025Article
- Hepatocellular Carcinoma Surveillance and Survival in a Contemporary Asia-Pacific Cohort.JAMA network open · 2025Article
- Flexible quantitative bias analysis for unmeasured confounding in subject-level indirect treatment comparisons with proportional hazards violation.BMC medical research methodology · 2025Article
- Use of menopausal hormone therapy before and after diagnosis and ovarian cancer survival-A prospective cohort study in Australia.International journal of cancer · 2025Article
- Delayed surgery among patients diagnosed with spinal disorders: Retrospective analysis.PloS one · 2025Article
- Pan-Cancer Survival Impact of Immune Checkpoint Inhibitors in a National Healthcare System.Cancer medicine · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
In observational studies with censored data, exposure-outcome associations are commonly measured with adjusted hazard ratios from multivariable Cox proportional hazards models. The difference in restricted mean survival times (RMSTs) up to a pre-specified time point is an alternative measure that offers a clinically meaningful interpretation. Several regression-based methods exist to estimate an adjusted difference in RMSTs, but they digress from the model-free method of taking the area under the survival function. We derive the adjusted RMST by integrating an adjusted Kaplan-Meier estimator with inverse probability weighting (IPW). The adjusted difference in RMSTs is the area between the two IPW-adjusted survival functions. In a Monte Carlo-type simulation study, we demonstrate that the proposed estimator performs as well as two regression-based approaches: the ANCOVA-type method of Tian et al and the pseudo-observation method of Andersen et al. We illustrate the methods by reexamining the association between total cholesterol and the 10-year risk of coronary heart disease in the Framingham Heart Study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.