Evidence map›Paper›PMID 31119700›Full record

ArticleObesity surgery2019

Effect of Sleeve Gastrectomy on Angiogenesis and Adipose Tissue Health in an Obese Animal Model of Type 2 Diabetes.

Hans Eickhoff, Tiago Rodrigues, Inês Neves, Daniela Marques, Diana Ribeiro, Susana Costa, Raquel Seiça, Paulo Matafome

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hans EickhoffObesity Center, Hospital da Luz Setúbal, EN 10, km 37, 2900-722, Setubal, Portugal. h.c.a.e@sapo.pt.ORCID 0000-0003-1416-456X
Tiago RodriguesInstitute of Physiology and Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Polo III, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal.
Inês NevesInstitute of Physiology and Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Polo III, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal.
Daniela MarquesInstitute of Physiology and Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Polo III, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal.
Diana RibeiroInstitute of Physiology and Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Polo III, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal.
Susana CostaInstitute of Physiology and Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Polo III, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal.
Raquel SeiçaInstitute of Physiology and Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Polo III, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal.
Paulo MatafomeInstitute of Physiology and Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Polo III, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal.
University of Coimbra · PTHospital da Luz · PTPolytechnic Institute of Coimbra · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMetabolic surgery has become an accepted option for the treatment of obesity and associated metabolic diseases like hypertension and type 2 diabetes. Adipose tissue dysfunction and ectopic storage of excess lipids are thought to be involved in the underlying pathophysiological process.

objectivesThe present study aims to clarify the effect of sleeve gastrectomy (SG) on adipose tissue microvasculature and health in an animal model of adipose type 2 diabetes.

methodsAfter weaning, diabetic Goto-Kakizaki rats were either fed on standard rat chow or high-calorie diet. At 4 months, animals on high-calorie diet were randomized to SG, sham surgery, or control group. Non-diabetic Wistar rats served as further controls. At 6 months, glucose and lipid metabolisms were studied in vivo. After sacrifice, periepididymal adipose tissue was collected for histology and analysis of parameters of adipose tissue metabolism and insulin sensitivity.

resultsSG decreased body and adipose tissue weight and improved glycemic and lipid profiles. Fasting glycemia, area under the curve after intraperitoneal insulin tolerance test, and insulin resistance were decreased in operated animals. SG also reduced circulating triglycerides and cholesterol while increasing serum adiponectin and adipose tissue peroxisome proliferator-activated receptor γ (PPAR-γ) and perilipin A. Additionally, surgery improved adipose tissue vascular function and markedly increased vascular endothelial growth factor, cluster of differentiation 31, and endothelial nitric oxide synthase.

conclusionsIn our obese animal model of type 2 diabetes, SG significantly improved adipose tissue health and angiogenesis while reducing insulin resistance, involving PPAR-γ and markers of sprouting angiogenesis and endothelial function.

Indexed as

GastrectomyAdiponectinAdipose TissueAnimalsBlood GlucoseDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Disease Models, AnimalLipid MetabolismMaleNeovascularization, PhysiologicObesity, MorbidRatsRats, WistarTriglyceridesVascular Endothelial Growth Factor AAdiponectinADIPOQ protein, humanBlood GlucoseTriglyceridesVascular Endothelial Growth Factor AAdipose tissueAngiogenesisAnimal modelSleeve gastrectomyType 2 diabetes

Identifiers

PMID31119700
OpenAlexW2946433997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.