Observational studyEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2019
White blood cell count and eosinopenia as valuable tools for the diagnosis of bacterial infections in the ED.
Observational study in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Low eosinophils and their dynamic as a predictor of death in patients with infections: a systematic review and meta-analysis of cohort studies.Annals of medicine · 2025Pooled it
- Silent existence of eosinopenia in sepsis: a systematic review and meta-analysis.BMC infectious diseases · 2021Pooled it
- Machine learning based retrospective cohort study to predict mortality risk in Chinese patients undergoing extracorporeal membrane oxygenation.Scientific reports · 2026Article
- Diagnostic performance of eosinopenia for identifying bacterial infections in the emergency department: a prospective multicenter study.BMC emergency medicine · 2026Article
- Inflammatory markers as predictors of severity in adult incarcerated groin hernias - a retrospective comparative study.BMC surgery · 2026Article
- Evaluation of zinc oxide and copper oxide nanoparticles as potential alternatives to antibiotics for managing fowl typhoid in broilers.Journal of animal science and technology · 2024Article
- Hematologic cancers and infections: how to detect infections in advance and determine the type?Frontiers in cellular and infection microbiology · 2024Review
- Article
- Characteristics of peripheral white blood cells in COVID-19 patients revealed by a retrospective cohort study.BMC infectious diseases · 2021Article
- COVID-19 coagulopathies: Human blood proteins mimic SARS-CoV-2 virus, vaccine proteins and bacterial co-infections inducing autoimmunity: Combinations of bacteria and SARS-CoV-2 synergize to induce autoantibodies targeting cardiolipin, cardiolipin-binding proteins, platelet factor 4, prothrombin, and coagulation factors.BioEssays : news and reviews in molecular, cellular and developmental biology · 2021Article
- The Value of a Complete Blood Count (CBC) for Sepsis Diagnosis and Prognosis.Diagnostics (Basel, Switzerland) · 2021Review
- A cross-sectional study on evaluation of complete blood count-associated parameters for the diagnosis of acute appendicitis.Health science reports · 2021Article
- Eosinophils and COVID-19: diagnosis, prognosis, and vaccination strategies.Seminars in immunopathology · 2021Review
- The role of eosinophils in sepsis and acute respiratory distress syndrome: a scoping review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2021Article
- Innate Receptor Activation Patterns Involving TLR and NLR Synergisms in COVID-19, ALI/ARDS and Sepsis Cytokine Storms: A Review and Model Making Novel Predictions and Therapeutic Suggestions.International journal of molecular sciences · 2021Review
- Do Blood Eosinophils Predict in-Hospital Mortality or Severity of Disease in SARS-CoV-2 Infection? A Retrospective Multicenter Study.Microorganisms · 2021Article
- Inflammatory Markers and Duration of Symptoms Have a Close Connection With Diagnosis and Staging of Acute Appendicitis in Children.Frontiers in pediatrics · 2021Article
- Eosinopenia in COVID-19 Patients: A Retrospective Analysis.Microorganisms · 2020Article
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Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying an infection may be difficult in the ED. Neutrophilic leukocytosis is often used in the diagnosis of infection despite its lack of specificity in situations of stress. Our objective was to study the value of each parameter of the WBC count, in particular eosinopenia, to diagnose bacterial infections in the ED. We conducted a retrospective and observational study over a period of 6 months. All patients with one of the following diagnoses were eligible: pneumonia (9.9%), pyelonephritis (26.2%), prostatitis (8.4%), appendicitis (26.2%), cholecystitis (8.4%), and diverticular sigmoiditis (5%). A total of 466 infected patients were included for statistical analysis, and a control group of 466 uninfected patients was randomly selected in the same period of time. All leukocyte count parameters were significantly modified (p < 0.001) in the infected group compared with the control group. Neutrophils and total leukocytes remain the two most suitable parameters for the diagnosis of infections in the ED. Eosinopenia represented the most efficient parameter of the WBC count for the diagnosis of urinary and biliary tract infections. Deep eosinopenia presented a specificity of 94% for the diagnosis of infection. Any modification of the WBC count associated with an elevation of CRP (> 40 mg/L) or fever (> 38.5 °C) showed a high specificity for the diagnosis of infection. A careful analysis of the WBC count remains a valuable tool for the diagnosis of infection in the ED.
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