Evidence map›Paper›PMID 31119505›Full record

ArticleInternational ophthalmology2019

Optical coherence tomography angiography analysis of macular vessel density before and after anti-VEGF therapy in eyes with diabetic retinopathy.

Osama A Sorour, Almyr S Sabrosa, A Yasin Alibhai, Malvika Arya, Akihiro Ishibazawa, Andre J Witkin, Caroline R Baumal, Jay S Duker, Nadia K Waheed

Registry-linked trialAbstract read
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In one paragraph

Article in International ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04594603 (Changes of Macular Vasculature After Uncomplicated Phacoemulsification Surgery Using Optical Coherence Tomography Angiography), which is not on this map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04594603 unknown statusnot on this mapstarted 2021, after this paper: background citation

Changes of Macular Vasculature After Uncomplicated Phacoemulsification Surgery Using Optical Coherence Tomography Angiography

Typeobservational_patient_registrySponsorTanta UniversityRan2021 to 2024Enrolled30ConditionsDiabetic RetinopathyArmsPhacoemulsification for cataract
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  16. Optical coherence tomography angiography in diabetic retinopathy.Progress in retinal and eye research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Osama A SorourNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Almyr S SabrosaNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
A Yasin AlibhaiNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Malvika AryaNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Akihiro IshibazawaNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Andre J WitkinNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Caroline R BaumalNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Jay S DukerNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Nadia K WaheedNew England Eye Center, Tufts Medical Center, Boston, MA, USA. nwaheed@tuftsmedicalcenter.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate changes in macular vessel density following intravitreal anti-VEGF injection in patients with diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR).

methodsIn this retrospective case series, optical coherence tomography angiography (OCTA) images from 55 eyes of 35 patients with either DME (46 eyes) or PDR (9 eyes) were included. Macular capillary vessel density at the level of the superficial retinal capillary plexus (SCP), deep retinal capillary plexus (DCP) and total retinal capillary plexus (TCP) before and after anti-VEGF treatment was calculated. Longitudinal changes in vessel density following serial anti-VEGF treatment were analyzed in a subset of eyes.

resultsVessel density in the SCP, DCP or TCP was not found to be significantly different after one, two or three intravitreal injections (p > 0.05 for all time points). Subgroup analysis revealed no significant change in the DME and PDR subgroups (all p > 0.05). Multivariate analysis revealed no effect of type of injected anti-VEGF agent or presence of previous treatment on VD measurements (all p > 0.05). There was no correlation between the anatomic response of DME to treatment and VD measurements.

conclusionsIn this study, macular vessel density remained statistically unchanged following up to three intravitreal injections of any anti-VEGF agent. This indicates that there may not be an early effect of anti-VEGF treatment on macular vessel density and its effect on macular perfusion may not be a direct change in microvascular flow.

Indexed as

AdultAgedAged, 80 and overAnalysis of VarianceAngiogenesis InhibitorsBevacizumabDiabetic RetinopathyFemaleFluorescein AngiographyHumansMacula LuteaMacular EdemaMaleMiddle AgedRanibizumabRetinal VesselsAngiogenesis InhibitorsBevacizumabRanibizumabVascular Endothelial Growth Factor AAfliberceptAnti-VEGFBevacizumab, diabetic retinopathyMacular edemaOptical coherence tomography angiographyProliferative diabetic retinopathyRanibizumabVessel density

Identifiers

PMID31119505

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Registered trials

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