Evidence map›Paper›PMID 31119493›Full record

ArticleClinical rheumatology2019

Behçet's disease in Egypt: a multicenter nationwide study on 1526 adult patients and review of the literature.

Tamer A Gheita, Eiman Abd El-Latif, Iman I El-Gazzar, Nermeen Samy, Nevin Hammam, Rasha A Abdel Noor, Emad El-Shebeiny, Amany R El-Najjar, Nahla N Eesa, Mohamed N Salem and 22 more

Erratum issued Registry-linked trialAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06060275 (Neurofilament Light Chain as a Potential Marker in Behcet's Disease), which is not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06060275 unknown statusnot on this mapstarted 2024, after this paper: background citation

Neurofilament Light Chain as a Potential Marker in Behcet's Disease

TypeobservationalSponsorAssiut UniversityRan2024 to 2024Enrolled60ConditionsBehçetArmsserum sample and nerve conduction study and cerebrospinal fluid study
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  10. Uveitis in paediatric Behçet disease: a large multicentric Italian cohort.Therapeutic advances in musculoskeletal disease · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Tamer A GheitaRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. gheitamer@hotmail.com.
Eiman Abd El-LatifOphthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Iman I El-GazzarRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Nermeen SamyInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Nevin HammamRheumatology Department, Faculty of Medicine, Assuit University, Assuit, Egypt.
Rasha A Abdel NoorInternal Medicine Department, Rheumatology Unit, Tanta University, Tanta, Gharbia, Egypt.
Emad El-ShebeinyInternal Medicine Department, Rheumatology Unit, Menoufia University, Shebeen El-Kom, Menoufia, Egypt.
Amany R El-NajjarRheumatology Department, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt.
Nahla N EesaRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed N SalemInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Soha E IbrahimRheumatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Dina F El-EssawiInternal Medicine Department, Rheumatology Unit (NCRRT), Atomic Energy Authority (AEA), Cairo, Egypt.
Ahmed M ElsamanRheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
Hanan M FathiRheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Rehab A SallamRheumatology Department, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia, Egypt.
Rawhya R El-ShereefRheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt.
Mervat I Abd-ElazeemRheumatology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Emtethal A SaidRheumatology Department, Faculty of Medicine, Benha University, Benha, Kalubia, Egypt.
Noha M KhalilInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Cairo University, Cairo, Egypt.
Dina ShahinInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia, Egypt.
Hanan M El-SaadanyRheumatology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Marwa S ElKhalifaInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Samah I NasefRheumatology Department, Faculty of Medicine, Suez-Canal University, Ismailia, Egypt.
Ahmed M AbdallaRheumatology Department, Faculty of Medicine, Aswan University, Aswan, Egypt.
Nermeen NoshyInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Rasha M FawzyRheumatology Department, Faculty of Medicine, Benha University, Benha, Kalubia, Egypt.
Ehab SaadRheumatology Department, Faculty of Medicine, South Valley University, Qena, Egypt.
Abdel-Hafeez MoshrifRheumatology Department, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.
Amira T El-ShanawanyRheumatology Department, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Menoufia, Egypt.
Yousra H Abdel-FattahRheumatology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Hossam M KhalilOphthalmology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Egyptian College of Rheumatology-Behçet’s Disease Study Group (ECR-BDSG)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe present work was conducted to estimate the prevalence of adult Behçet's disease (BD) in adult Egyptian and to study the clinical pattern and influence of age at-onset and sex on disease phenotype. Also, we investigated the spectrum of presentation and frequencies along the north-to-south gradient of the country. PATIENTS AND

methodThe population-based, multicenter, cross-sectional study included 1526 adult BD patients from 26 specialized Egyptian rheumatology centers. Demographic, clinical, and therapeutic data are assessed for all patients.

resultsThe mean age of patients was 35.7 ± 9.84 years, disease duration 6.58 ± 5.25 years, and age at onset 29.37 ± 8.6 years; 91 were juvenile-onset (JoBD). There were 1102 males and 424 females (M:F 2.6:1). Regarding co-morbidities, 19.92% were diabetic, and 26.05% were hypertensive. The mean body mass index was 27.57 ± 5.24 (43.1% overweight; 25.9% obese). The mean BD current activity form was 4.48 ± 4.28. Regarding the medications use, systemic steroid and colchicine were the most common drugs used (947 (90.2%) and 611 (82.7%), respectively). The overall estimated prevalence of BD in Egypt was 3.6/100,000 population being highest in the two main cities: Alexandria (15.27) and Cairo (8.72). Pathergy test was positive in 43.4%. 90.2% were receiving systemic steroids and 8.3%, biologics. Disease characteristics were comparable between JoBD and adult-onset BD cases. Central nervous system (CNS), deep venous thrombosis (DVT), and gastrointestinal (GIT) involvement were significantly higher in males (p = 0.01, p = 0.001, and p = 0.001 respectively) while joint affection (p = 0.001) and disease activity (p = 0.011) were increased in females.

conclusionsThis study provides current prevalence of BD in Egypt; 3.6/100,000 with no remarkable north-to-south gradient. The sex influences the disease phenotype with the CNS, DVT, and GIT involvement are higher in males, while the joint affection and disease activity were increased in females. KEY POINTS: • The prevalence and phenotype of Behçet's disease across Egypt is presented in a multicenter nationwide study. • The potential influence of the age at onset and sex on disease phenotype is highlightened. • A review of the literature worldwide is presented allowing comparisons with studies from other nations.

Indexed as

AdolescentAdultAgedAge of OnsetBehcet SyndromeColchicineComorbidityCross-Sectional StudiesEgyptFemaleHumansMaleMiddle AgedPhenotypePrevalenceSex FactorsColchicineAge at onsetBehçet’s diseaseEgyptMulticenterPrevalenceSex

Identifiers

PMID31119493

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.