ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020
Prognostic accuracy of the sequential organ failure assessment (SOFA) and quick SOFA for mortality in cancer patients with sepsis defined by systemic inflammatory response syndrome (SIRS).
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Construction of a sensitive indicator evaluation system for sepsis care quality: a three-stage mixed-method Delphi study.Frontiers in medicine · 2026Pooled it
- Pooled it
- A prediction model for 30-day mortality of sepsis patients based on intravenous fluids and electrolytes.Medicine · 2022Trial
- Machine learning for prediction of 30-day mortality in patients with advanced cancer: comparing pan-cancer and single-cancer models.ESMO real world data and digital oncology · 2025Article
- Hierarchical Capability in Distinguishing Severities of Sepsis via Serum Lactate: A Network Meta-Analysis.Biomedicines · 2024Review
- Article
- The Predictive Value of Heparin-Binding Protein and D-Dimer in Patients with Sepsis.International journal of general medicine · 2023Article
- Splenic SUMO1 controls systemic inflammation in experimental sepsis.Frontiers in immunology · 2023Article
- Development and validation of a new risk scoring system for solid tumor patients with suspected infection.Scientific reports · 2022Article
- Elevation of the D-dimer cut-off level might be applicable to rule out pulmonary embolism for active cancer patients in the emergency department.Internal and emergency medicine · 2022Observational
- Outcomes and Risk Factors of Critically Ill Patients with Hematological Malignancy. Prospective Single-Centre Observational Study.Medicina (Kaunas, Lithuania) · 2021Observational
- Brain natriuretic peptide and cardiac troponin I for prediction of the prognosis in cancer patients with sepsis.BMC anesthesiology · 2021Article
- Impact of Body Composition Status on 90-Day Mortality in Cancer Patients with Septic Shock: Sex Differences in the Skeletal Muscle Index.Journal of clinical medicine · 2019Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeWe aimed to assess the prognostic accuracy of SOFA and qSOFA scores in cancer patients with sepsis, and also to determine if the addition of hyperlactatemia to qSOFA increases the accuracy in predicting the 30-day mortality. MATERIAL AND
methodWe consecutively included adult active cancer patients (age ≥ 18 years) with sepsis defined by SIRS who visited the emergency department (ED) from May 1st to July 30th, 2017. Data were collected retrospectively through reviewing medical records. The SOFA and qSOFA scores were calculated with the initial variables at the time of ED admission. The primary endpoint was 30-day mortality.
resultOf 1137 screened, 301 were included. The 30-day mortality was 14.3% (43 patients). Among the total 301, the SOFA score was ≥ 2 in 168 and qSOFA ≥ 2 in 23. For those with SOFA ≥ 2 and < 2, the mortality was 23.2% and 3%, respectively (P < 0.001). For those with qSOFA ≥ 2 and < 2, the mortality was 47.8% and 11.5%, respectively (P < 0.001). The AUROC of 30-day mortality for qSOFA was lower than that for SOFA (0.66 (95% CI, 0.56-0.75) vs. 0.79 (95% CI, 0.72-0.87), P = 0.004)). However, the combination of qSOFA with lactate ≥ 2 threshold considerably enhanced a discrimination capacity for mortality with an AUROC 0.77 (95% CI, 0.69-0.85), which was similar to SOFA (P = 0.11).
conclusionIn cancer patients with sepsis, qSOFA was inferior to SOFA in predicting mortality. However, adding lactate to qSOFA resulted in greater prognostic accuracy for short-term mortality, comparable with SOFA.
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