ArticleSocial cognitive and affective neuroscience2019
Patients with dorsolateral prefrontal cortex lesions are capable of discriminatory threat learning but appear impaired in cognitive regulation of subjective fear.
Article in Social cognitive and affective neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review on the Effect of Transcranial Direct Current and Magnetic Stimulation on Fear Memory and Extinction.Frontiers in human neuroscience · 2021Pooled it
- Sustained dorsolateral prefrontal cortex response to prosocial reward predicts lower real-world negative emotional inertia.Cognitive, affective & behavioral neuroscience · 2026Article
- A visual generalization gradient of conceptual stimuli based on fear acquisition in visual and auditory modalities.NPJ science of learning · 2025Article
- Prefrontal correlates of fear generalization during endocannabinoid depletion.The Journal of clinical investigation · 2025Article
- Frontocortical activity and emotional experience in the context of daily life events.Social cognitive and affective neuroscience · 2025Article
- Emotional salience network involved in constructing two-dimensional fear space in humans.Neurobiology of stress · 2025Review
- The Dorsolateral Prefrontal Cortex: A High-level Hub for Allostatic Cardiovascular Control.Current neuropharmacology · 2025Review
- [Neural mechanisms of fear responses to emotional stimuli: a preliminary study combining early posterior negativity and electroencephalogram source network analysis].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research.Molecular psychiatry · 2024Review
- Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder.Journal of affective disorders · 2024Article
- The maintenance of complex visual scenes in working memory may require activation of working memory manipulation circuits in the dlPFC: a preliminary report.Mental health science · 2024Article
- Conflict Dynamics of Post-Retrieval Extinction: A Comparative Analysis of Unconditional and Conditional Reminders Using Skin Conductance Responses and EEG.Brain topography · 2024Article
- Within-person biological mechanisms of mood variability in childhood and adolescence.Human brain mapping · 2024Article
- Metacognition as a window into subjective affective experience.Psychiatry and clinical neurosciences · 2024Review
- Resting-state brain activity as a biomarker of chronic pain impairment and a mediator of its association with pain resilience.Human brain mapping · 2024Article
- PREFRONTAL CORRELATES OF FEAR GENERALIZATION DURING ENDOCANNABINOID DEPLETION.bioRxiv : the preprint server for biology · 2024Article
- Conscious expectancy rather than associative strength elicits brain activity during single-cue fear conditioning.Social cognitive and affective neuroscience · 2023Article
- Hemodynamic correlates of emotion regulation in frontal lobe epilepsy patients and healthy participants.Human brain mapping · 2023Article
- The role of dlPFC laterality in the expression and regulation of anxiety.Neuropharmacology · 2023Review
- Neural circuitry involved in conditioned inhibition via safety signal learning is sensitive to trauma exposure.Neurobiology of stress · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Humans are able to cognitively regulate emotions by changing their thoughts. Neuroimaging studies show correlations between dorsolateral prefrontal cortex (dlPFC) activity and cognitive regulation of emotions. Here our objective was to investigate whether dlPFC damage is associated with impaired cognitive regulation of emotion. We therefore tested the ability of patients with dlPFC lesions (N = 6) and matched control participants (N = 19) to utilize a laboratory version of cognitive regulation training (CRT) to regulate subjective fear and autonomic threat responses following Pavlovian threat conditioning. We found that patients with dlPFC lesions were able to acquire conditioned threat but seemed impaired in their ability to utilize CRT to cognitively regulate subjective fear to a threatening stimulus. Despite inclusion of a limited number of lesion patients, our results suggest that the dlPFC is important for the cognitive regulation of subjective fear.
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