Evidence map›Paper›PMID 31119153›Full record

ArticleBioMed research international2019

Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation.

Carmel J W Stock, Charalambos Michaeloudes, Patricia Leoni, Andrew L Durham, Sharon Mumby, Athol U Wells, Kian Fan Chung, Ian M Adcock, Elisabetta A Renzoni, Gisela E Lindahl

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. BRD4 as a Therapeutic Target in Pulmonary Diseases.International journal of molecular sciences · 2023
    Review
  8. Review
  9. Article
  10. Article
  11. Insights into Manganese Superoxide Dismutase and Human Diseases.International journal of molecular sciences · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. The networks of mAging · 2021
    Article
  18. Role of BET Proteins in Inflammation and CNS Diseases.Frontiers in molecular biosciences · 2021
    Review
  19. NADPH Oxidase Inhibition in Fibrotic Pathologies.Antioxidants & redox signaling · 2020
    Article
  20. Metabolic Dysregulation in Idiopathic Pulmonary Fibrosis.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Carmel J W Stock *Interstitial Lung Disease Unit, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Charalambos Michaeloudes *Airway Disease Section, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.ORCID 0000-0002-4107-4028
Patricia Leoni *Interstitial Lung Disease Unit, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Andrew L DurhamAirway Disease Section, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Sharon MumbyAirway Disease Section, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Athol U WellsInterstitial Lung Disease Unit, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Kian Fan ChungAirway Disease Section, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Ian M AdcockAirway Disease Section, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.ORCID 0000-0003-2101-8843
Elisabetta A RenzoniInterstitial Lung Disease Unit, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Gisela E LindahlInterstitial Lung Disease Unit, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Imperial College London · GBRoyal Brompton Hospital · GB

Funding

Versus Arthritis 20719
6 · The paper itself

Abstract

BACKGROUND AND

objectiveProgressive pulmonary fibrosis is the main cause of death in patients with systemic sclerosis (SSc) with interstitial lung disease (ILD) and in those with idiopathic pulmonary fibrosis (IPF). Transforming growth factor-

methodsIn TGF- RESULTS AND

conclusionsAffymetrix gene array analysis revealed increased

Indexed as

AzepinesBromodomain Containing ProteinsCell Cycle ProteinsCell DedifferentiationCell ProliferationEpigenesis, GeneticGene Expression RegulationHumansIdiopathic Pulmonary FibrosisLungMyofibroblastsNADPH Oxidase 4NF-E2-Related Factor 2Nuclear ProteinsOxidation-ReductionReactive Oxygen SpeciesAzepinesBRD3 protein, humanBRD4 protein, humanBromodomain Containing ProteinsCell Cycle Proteins(+)-JQ1 compoundNADPH Oxidase 4NFE2L2 protein, humanNF-E2-Related Factor 2Nuclear ProteinsReactive Oxygen SpeciesRNA-Binding ProteinsRNA, Small InterferingSuperoxide DismutaseSuperoxide Dismutase 2Transcription FactorsTransforming Growth Factor betaTriazoles

Identifiers

PMID31119153
PMCPMC6500679
OpenAlexW2940403538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.