ArticleCancer biology & medicine2019
Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study.
Article in Cancer biology & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 24 citations in OpenAlex.
- Features of low-dose CT-detected lung nodules: individuals who never smoked vs. who smoke(d) in a Chinese general population.European radiology · 2026Article
- A narrative review on CT-based evaluation and prediction of lung nodule growth: current status and future directions.Translational lung cancer research · 2026Review
- Association Between Emphysema and Coronary Artery Calcium on Low-Dose CT in Urban Chinese Adults: Does Lifestyle Matter?Healthcare (Basel, Switzerland) · 2026Article
- Artificial intelligence as an independent reader of risk-dominant lung nodules: influence of CT reconstruction parameters.European radiology · 2026Article
- Phantom-based evaluation of radiomics feature stability for low-dose CT lung cancer screening.Frontiers in endocrinology · 2026Article
- Respiratory symptoms associated with a new lobe-based bronchial scoring system in an urban Chinese low-dose CT screening population.European radiology · 2025Article
- Co-occurrence of bronchiectasis, airway wall thickening, and emphysema in Chinese low-dose CT screening.European radiology · 2025Article
- Thoracic vertebral bone mineral density measured by quantitative computed tomography is associated with fracture risk in lung cancer screening populations: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Association between visual emphysema and lung nodules on low-dose CT scan in a Chinese Lung Cancer Screening Program (Nelcin-B3).European radiology · 2022Article
- Cost-effectiveness of lung cancer screening by low-dose CT in China: a micro-simulation study.Journal of the National Cancer Center · 2022Article
- Comparison of National Comprehensive Cancer Network and European Position Statement protocols for nodule management in low-dose computed tomography lung cancer screening in a general Chinese population.Journal of thoracic disease · 2021Article
- Latest CT technologies in lung cancer screening: protocols and radiation dose reduction.Translational lung cancer research · 2021Review
- Article
- A DNA quantitative analysis of lung cancer cells with different pathological types from bronchial brush specimens and its clinical significance.International journal of clinical and experimental pathology · 2020Article
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEuropean lung cancer screening studies using computed tomography (CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time (VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.
methodsThis study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol (Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT (a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.
resultsThe diagnostic performance of volume- and diameter-based management for lung nodules in a Chinese population will be estimated and compared.
conclusionsThrough the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations.
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