ArticleCancer biology & medicine2019
Memory stem T cells generated by Wnt signaling from blood of human renal clear cell carcinoma patients.
Article in Cancer biology & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- IL-7/IL-15/IL-21 cytokine-fusion scaffold generates highly functional CAR T cells enriched in long-lived T memory stem cells.Science advances · 2026Article
- Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Wnt signaling as a regulator of memory T cells: implications for CAR-T cell therapy.Frontiers in immunology · 2026Review
- Optimizing CD8Experimental hematology & oncology · 2024Review
- Review
- A strategy to reconstitute immunity without GVHD via adoptive allogeneic Tscm therapy.Frontiers in immunology · 2024Article
- Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-TSCM cells using a Quantum pBac-based CAR-T engineering system.PloS one · 2024Article
- New insights into the stemness of adoptively transferred T cells by γc family cytokines.Cell communication and signaling : CCS · 2023Review
- Total T Cell Density and Expression of T Memory Stem Cell Markers are Associated with Better Prognosis in Colon Cancer.International journal of general medicine · 2023Article
- Stem-like T cells and niches: Implications in human health and disease.Frontiers in immunology · 2022Review
- Cellular networks controlling T cell persistence in adoptive cell therapy.Nature reviews. Immunology · 2021Review
- Immunotherapeutic Potential of T Memory Stem Cells.Frontiers in oncology · 2021Review
- Modulation of Determinant Factors to Improve Therapeutic Combinations with Immune Checkpoint Inhibitors.Cells · 2020Review
- CD40 Accelerates the Antigen-Specific Stem-Like Memory CD8Frontiers in immunology · 2020Article
- Next-Generation Manufacturing Protocols Enriching TFrontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMemory stem T cells (Tscm) have attracted attention because of their enhanced self-renewal, multipotent capacity, and anti-tumor capacities. However, little is known about Tscm in patients with renal clear cell carcinoma (RCC) and the role of Wnt signaling in these cells. We evaluated Tscm from RCC patients concerning their activation of Wnt signaling
methodsFlow cytometry identified surface markers and cytokines produced from accumulated Tscm in the presence of the glycogen synthase kinase beta inhibitor TWS119. Apoptosis was evaluated after induction using tumor necrosis factor-alpha. Immunofluorescence and Western blot analyses were used to investigate the activation of the nuclear factor-kappa B (NF-КB) pathway.
resultsRCC patients had a similar percentage of CD4
conclusionsThe finding that Tscm can accumulate by Wnt signaling
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