ArticleCancer biology & medicine2019
Qidong: a crucible for studies on liver cancer etiology and prevention.
Article in Cancer biology & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Environmental risk factors for liver cancer.Hepatology (Baltimore, Md.) · 2025Article
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- Profound primary prevention of liver cancer following a natural experiment in China: A 50-year perspective and public health implications.International journal of cancer · 2025Article
- Fifty Years of Aflatoxin Research in Qidong, China: A Celebration of Team Science to Improve Public Health.Toxins · 2025Review
- Article
- Liver Cancer Etiology: Old Issues and New Perspectives.Current oncology reports · 2024Review
- Tumor Growth in Overdrive: Detailing an Aggressive Course of Hepatocellular Carcinoma.Case reports in hepatology · 2024Article
- Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers.Cancer metastasis reviews · 2023Review
- Functional analyses of single nucleotide polymorphic variants of the DNA glycosylase NEIL1 in sub-Saharan African populations.DNA repair · 2023Article
- Hepatocellular carcinoma and intrahepatic cholangiocarcinoma incidence between 2006 and 2015 in China: estimates based on data from 188 population-based cancer registries.Hepatobiliary surgery and nutrition · 2023Article
- Cancer situation in China: what does the China cancer map indicate from the first national death survey to the latest cancer registration?Cancer communications (London, England) · 2023Article
- Article
- Comparing spatial patterns of 11 common cancers in Mainland China.BMC public health · 2022Article
- Network Pharmacology and Bioinformatics Approach Reveals the Multi-Target Pharmacological Mechanism ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Assessing the Validity of Normalizing Aflatoxin BToxins · 2022Article
- Attributable deaths of liver cancer in China.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2021Article
- Article
- Aflatoxin and the Etiology of Liver Cancer and Its Implications for Guatemala.World mycotoxin journal · 2021Article
- A Primary Screening Method for Liver Cancer in Chronic Hepatitis B Carriers: A Prospective Community-Based Cohort Study.Frontiers in oncology · 2021Article
- Genetic Variant of PP2A Subunit Gene Confers an Increased Risk of Primary Liver Cancer in Chinese.Pharmacogenomics and personalized medicine · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Qidong (Jiangsu, China) has been of interest to cancer epidemiologists and biologists because, until recently, it was an endemic area for liver cancer, having amongst the highest incidence rates in the world. The establishment of the Qidong Cancer Registry together with the Qidong Liver Cancer Institute in 1972 has charted the patterns of liver cancer incidence and mortality in a stable population throughout a period of enormous economic, social, and environmental changes as well as of improvements in health care delivery. Updated incidence trends in Qidong are described. Notably, the China age-standardized incidence rate for liver cancer has dropped by over 50% in the past several decades. Molecular epidemiologic and genomic deep sequencing studies have affirmed that infection with hepatitis B virus as well as dietary exposure to aflatoxins through contamination of dietary staples such as corn, and to microcystins - blue-green algal toxins found in ditch and pond water - were likely important etiologic factors that account for the high incidence of liver cancer in this region. Public health initiatives to facilitate universal vaccination of newborns against HBV and to improve drinking water sources in this rural area, as well as economic and social mandates serendipitously facilitating dietary diversity, have led to precipitous declines in exposures to these etiologic factors, concomitantly driving substantive declines in the liver cancer incidence seen now in Qidong. In this regard, Qidong serves as a template for the global impact that a package of intervention strategies may exert on cancer burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.