Evidence map›Paper›PMID 31118938›Full record

ArticleFrontiers in immunology2019

Dopamine Receptor D3 Expression Is Altered in CD4

Daniela Elgueta, Francisco Contreras, Carolina Prado, Andro Montoya, Valentina Ugalde, Ornella Chovar, Roque Villagra, Claudio Henríquez, Miguel A Abellanas, María S Aymerich and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Observational
  5. Review
  6. Article
  7. Dopaminergic signalling in gastrointestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Dopamine, Immunity, and Disease.Pharmacological reviews · 2023
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Daniela ElguetaLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, Santiago, Chile.
Francisco ContrerasLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, Santiago, Chile.
Carolina PradoLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, Santiago, Chile.
Andro MontoyaLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, Santiago, Chile.
Valentina UgaldeLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, Santiago, Chile.
Ornella ChovarLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, Santiago, Chile.
Roque VillagraDepartamento de Ciencias Neurológicas Oriente, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Claudio HenríquezDepartamento de Ciencias Neurológicas Oriente, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Miguel A AbellanasDepartamento de Bioquímica y Genética, Programa de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, Spain.
María S AymerichDepartamento de Bioquímica y Genética, Programa de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, Spain.
Rarael FrancoDepartment of Biochemistry and Molecular Biomedicine, University of Barcelona, Barcelona, Spain.
Rodrigo PachecoLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, Santiago, Chile.
Fundación Ciencia and Vida · CLUniversidad de Navarra · ESUniversity of Chile · CLUniversitat de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation constitutes a fundamental process involved in Parkinson's disease (PD). Microglial cells play a central role in the outcome of neuroinflammation and consequent neurodegeneration of dopaminergic neurons in the substantia nigra. Current evidence indicates that CD4

Indexed as

AgedAnimalsBenzamidesCD4-Positive T-LymphocytesDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMiddle AgedMotor DisordersParkinson DiseaseParkinsonian DisordersPyridinesReceptors, Dopamine D3BenzamidesN-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)but-2-enyl)-4-pyridine-2-ylbenzamidePyridinesReceptors, Dopamine D3CD4+ T-cellsdopamine receptorsMPTP mouse modelneurodegenerationneuroinflammationParkinson's disease patients

Identifiers

PMID31118938
PMCPMC6504698
OpenAlexW2943768381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.