Evidence map›Paper›PMID 31118929›Full record

ArticleFrontiers in immunology2019

Immunological Molecular Responses of Human Retinal Pigment Epithelial Cells to Infection With

Shervi Lie, Elise Rochet, Erik Segerdell, Yuefang Ma, Liam M Ashander, Audra M A Shadforth, Timothy A Blenkinsop, Michael Z Michael, Binoy Appukuttan, Beth Wilmot and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Putative mechanisms of ocular inflammation in syphilis.Journal of ophthalmic inflammation and infection · 2026
    Review
  2. Article
  3. Article
  4. Human Retinal Organoid Model of Ocular Toxoplasmosis.Pathogens (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Human retinal endothelial cells express functional interleukin-6 receptor.Journal of ophthalmic inflammation and infection · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Seronegative ocular toxoplasma panuveitis in an immunocompetent patient.American journal of ophthalmology case reports · 2020
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Shervi LieEye and Vision Health, Flinders University College of Medicine and Public Health, Adelaide, SA, Australia.
Elise RochetEye and Vision Health, Flinders University College of Medicine and Public Health, Adelaide, SA, Australia.
Erik SegerdellDepartment of Biostatistics, Oregon Health and Sciences University, Portland, OR, United States.
Yuefang MaEye and Vision Health, Flinders University College of Medicine and Public Health, Adelaide, SA, Australia.
Liam M AshanderEye and Vision Health, Flinders University College of Medicine and Public Health, Adelaide, SA, Australia.
Audra M A ShadforthQueensland Eye Institute, Brisbane, QLD, Australia.
Timothy A BlenkinsopDepartments of Cell, Developmental and Regenerative Biology, and Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Michael Z MichaelFlinders Centre for Innovation in Cancer, Flinders University College of Medicine and Public Health, Adelaide, SA, Australia.
Binoy AppukuttanEye and Vision Health, Flinders University College of Medicine and Public Health, Adelaide, SA, Australia.
Beth WilmotDepartment of Biostatistics, Oregon Health and Sciences University, Portland, OR, United States.
Justine R SmithEye and Vision Health, Flinders University College of Medicine and Public Health, Adelaide, SA, Australia.
Flinders University · AUOregon Health & Science University · USIcahn School of Medicine at Mount Sinai · USQueensland University of Technology · AU

Funding

Reversing Contractility in Epiretinal MembranesR01EY029736 · NEI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BLENKINSOP, TIMOTHY A. · 2020 to 2024
$2.0M
NEI NIH HHS R01 EY029736
6 · The paper itself

Abstract

Ocular toxoplasmosis is the commonest clinical manifestation of infection with obligate intracellular parasite,

Indexed as

AgedCadaverCell Culture TechniquesCell LineCell SeparationGene Expression ProfilingGene OntologyGene Regulatory NetworksHumansImmunogenetic PhenomenaMicroRNAsMiddle AgedRetinal Pigment EpitheliumRNA-SeqToxoplasmaToxoplasmosis, OcularMicroRNAsMIRN146 microRNA, humanMIRN212 microRNA, humangene ontologyhumaninfectionnetworkpathwayretinal pigment epitheliumRNA-sequencingToxoplasma gondii

Identifiers

PMID31118929
PMCPMC6506780
OpenAlexW2942514636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.