Evidence map›Paper›PMID 31118901›Full record

ArticleFrontiers in physiology2019

Pleiotropic Effects of

Jonathan H Massey, Noriyoshi Akiyama, Tanja Bien, Klaus Dreisewerd, Patricia J Wittkopp, Joanne Y Yew, Aya Takahashi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Hippo signaling regulates cuticle pigmentation and dopamine metabolism inbioRxiv : the preprint server for biology · 2025
    Article
  6. RNAi-based screen for pigmentation inbioRxiv : the preprint server for biology · 2025
    Article
  7. Evolution letters · 2025
    Article
  8. Article
  9. Article
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  11. CRISPR/Cas9-mediated knock-in inGene and genome editing · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Silencing ofFrontiers in physiology · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Jonathan H MasseyDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, United States.
Noriyoshi AkiyamaDepartment of Biological Sciences, Tokyo Metropolitan University, Hachioji, Japan.
Tanja BienInstitute for Hygiene, University of Münster, Münster, Germany.
Klaus DreisewerdInstitute for Hygiene, University of Münster, Münster, Germany.
Patricia J WittkoppDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, United States.
Joanne Y YewPacific Biosciences Research Center, University of Hawai'i at Mānoa, Honolulu, HI, United States.
Aya TakahashiDepartment of Biological Sciences, Tokyo Metropolitan University, Hachioji, Japan.
Tokyo Metropolitan University · JPUniversity of Münster · DEJanelia Research Campus · USUniversity of Hawaiʻi at Mānoa · USUniversity of Michigan–Ann Arbor · US

Funding

The Control of Insect Metabolism through Nutrition-based SymbiosisP20GM125508 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Anthony Amend · 2018 to 2026
$21.2M
PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
Genetic mechanisms and evolutionary processes underlying diversity within and between speciesR35GM118073 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WITTKOPP, PATRICIA JEAN · 2016 to 2025
$4.1M
NIGMS NIH HHS P20 GM125508NIGMS NIH HHS R35 GM118073NIGMS NIH HHS T32 GM007544
6 · The paper itself

Abstract

Pleiotropic genes are genes that affect more than one trait. For example, many genes required for pigmentation in the fruit fly

Indexed as

cuticular hydrocarbonsdopamineDrosophilaebonypigmentationpleiotropytantrait covariation

Identifiers

PMID31118901
PMCPMC6504824
OpenAlexW2953027210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.