ArticleFrontiers in cellular neuroscience2019
Technologies to Study Action Potential Propagation With a Focus on HD-MEAs.
Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Electrical Stimulation-Induced Modulation of Small Extracellular Vesicles in Regenerative Therapy.Tissue engineering and regenerative medicine · 2026Review
- Extracellular Spike Waveforms: Morphology, Biophysics, and Classification Strategies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Distributional invariance and proportional scaling in axonal conduction.Biophysical journal · 2026Article
- Smart Polymeric 3D Microscaffolds Hosting Spheroids for Neuronal Research via Quantum Metrology.Advanced healthcare materials · 2025Article
- Functionalized Nanodiamonds for Targeted Neuronal Electromagnetic Signal Detection.ACS applied materials & interfaces · 2024Article
- Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- CardioMEA: comprehensive data analysis platform for studying cardiac diseases and drug responses.Frontiers in physiology · 2024Article
- Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body - a comprehensive review.Frontiers in network physiology · 2024Review
- Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes.Communications biology · 2023Article
- Supertemporal Resolution Imaging of Membrane Potential via Stroboscopic Microscopy.Chemical & biomedical imaging · 2023Article
- Microscopic-scale magnetic recording of brain neuronal electrical activity using a diamond quantum sensor.Scientific reports · 2023Article
- Two firing modes and well-resolved NaPflugers Archiv : European journal of physiology · 2023Article
- Repeated and On-Demand Intracellular Recordings of Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells.ACS sensors · 2022Article
- Neuronal Activity Reporters as Drug Screening Platforms.Micromachines · 2022Review
- Differences in action potential propagation speed and axon initial segment plasticity between neurons from Sprague-Dawley rats and C57BL/6 mice.Zoological research · 2022Article
- Impedance Imaging of Cells and Tissues: Design and Applications.BME frontiers · 2022Article
- A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials.Brain : a journal of neurology · 2022Article
- An automated method for precise axon reconstruction from recordings of high-density micro-electrode arrays.Journal of neural engineering · 2022Article
- Discovering Microcircuit Secrets With Multi-Spot Imaging and Electrophysiological Recordings: The Example of Cerebellar Network Dynamics.Frontiers in cellular neuroscience · 2022Review
- Engineered Biological Neural Networks on High Density CMOS Microelectrode Arrays.Frontiers in neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axons convey information in neuronal circuits via reliable conduction of action potentials (APs) from the axon initial segment (AIS) to the presynaptic terminals. Recent experimental findings increasingly evidence that the axonal function is not limited to the simple transmission of APs. Advances in subcellular-resolution recording techniques have shown that axons display activity-dependent modulation in spike shape and conduction velocity, which influence synaptic strength and latency. We briefly review here, how recent methodological developments facilitate the understanding of the axon physiology. We included the three most common methods, i.e., genetically encoded voltage imaging (GEVI), subcellular patch-clamp and high-density microelectrode arrays (HD-MEAs). We then describe the potential of using HD-MEAs in studying axonal physiology in more detail. Due to their robustness, amenability to high-throughput and high spatiotemporal resolution, HD-MEAs can provide a direct functional electrical readout of single cells and cellular ensembles at subcellular resolution. HD-MEAs can, therefore, be employed in investigating axonal pathologies, the effects of large-scale genomic interventions (e.g., with RNAi or CRISPR) or in compound screenings. A combination of extracellular microelectrode arrays (MEAs), intracellular microelectrodes and optical imaging may potentially reveal yet unexplored repertoires of axonal functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.