ReviewInternational journal of nephrology and renovascular disease2019
Dialysis disequilibrium syndrome prevention and management.
Review in International journal of nephrology and renovascular disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Interventions for preventing haemodialysis dysequilibrium syndrome.The Cochrane database of systematic reviews · 2024Pooled it
- Efficacy of two hemodialyses in patients with chronic renal failure complicated by massive intracerebral hemorrhage.Annals of clinical and translational neurology · 2023Trial
- Intractable dialysis-associated headache: a management dilemma in pediatric hemodialysis.Pediatric nephrology (Berlin, Germany) · 2026Article
- What is the best dialysis regimen for severe AKI to allow kidney function recovery?Clinical kidney journal · 2026Review
- Corneal densitometry and anterior segment changes in patients undergoing maintenance hemodialysis.International ophthalmology · 2026Observational
- Dialysis disequilibrium syndrome: an underdiagnosed condition? Results from a monocentric observational study.Clinical kidney journal · 2026Article
- Article
- Article
- Neurological Complications After Pediatric Liver and Kidney Transplantation: A Comprehensive Review of Acute Symptomatic Seizures.Pediatric transplantation · 2026Review
- Prognostic Factors of 30-Day In-Hospital Mortality in Critically Ill Patients Receiving Continuous Renal Replacement Therapy.The journal of nursing research : JNR · 2026Observational
- Article
- Fatal Spinal Cord Edema Following Cervical Decompression Surgery Possibly Associated with Dialysis Disequilibrium Syndrome: A Case Report.JMA journal · 2026Article
- Dialysis disequilibrium syndrome: An overview of the current neurosurgical state.Surgical neurology international · 2026Article
- Article
- Article
- Enhancing outcomes in pediatric populations with continuous renal replacement therapy: Current multidisciplinary strategies and innovations.Journal of intensive medicine · 2025Review
- Dialysis Disequilibrium Syndrome as a Cause of Unexplained Pain in a Young Female: A Case Report.Cureus · 2025Article
- Article
- Evaluation of intermittent hemodialysis therapy in the bypass mode in dogs with chronic kidney disease in uremic crisis.BMC veterinary research · 2025Article
- Cerebral Hemodynamic Alterations in Dialysis COVID-19 Survivors: A Transcranial Doppler Ultrasound Study on Intracranial Pressure Dynamics.Kidney and dialysis · 2025Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dialysis disequilibrium syndrome (DDS) is a clinical constellation of neurologic symptoms and signs occurring during or shortly following dialysis, especially when dialysis is first initiated. It is a diagnosis of exclusion occurring in those that are uremic and hyperosmolar, in whom rapid correction with renal replacement therapy leads to cerebral edema and raised intracranial pressure with resultant clinical neurologic manifestations. DDS is most commonly described in association with hemodialysis but can occur in patients with acute kidney injury requiring continuous renal replacement therapy (CRRT). To date, it has not been described in association with peritoneal dialysis. The syndrome is uncommon and becoming rarer, so performing randomized controlled trials to evaluate the effectiveness of potential therapies is almost impossible. This also makes studying the pathophysiology in humans challenging. It is associated with mortality but is also preventable, so identification of patients at risk, preventive measures, early recognition and prompt management of DDS will minimize morbidity and mortality associated with this syndrome. While the focus of this review is the prevention and management of DDS, there will be an emphasis on what is known about the pathophysiology because it strongly impacts the prevention and management strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.