Evidence map›Paper›PMID 31118670›Full record

ArticleOncoTargets and therapy2019

Antitumor activity of larotrectinib in tumors harboring

Biagio Ricciuti, Carlo Genova, Lucio Crinò, Massimo Libra, Giulia Costanza Leonardi

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in OncoTargets and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 51 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Reimagining the Therapeutic Approach for Anaplastic Thyroid Cancer: The Roadmap to a Cure.Thyroid : official journal of the American Thyroid Association · 2025
    Review
  6. Article
  7. The Future of Precision Oncology.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Toward in vivo proof of binding ofEJNMMI research · 2022
    Article
  10. A review of NTRK fusions in cancer.Annals of medicine and surgery (2012) · 2022
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Targeting apoptosis in cancer therapy.Nature reviews. Clinical oncology · 2020
    Review
  17. Article
  18. International journal of molecular sciences · 2020
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Biagio RicciutiDepartment of Medical Oncology, Thoracic Oncology Unit, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.
Carlo GenovaLung Cancer Unit, Ospedale Policlinico San Martino, Genova 16132, Italy.
Lucio CrinòDepartment of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy.
Massimo LibraDepartment of Biomedical and Biotechnological Sciences, Pathology and Oncology Section, University of Catania, Catania, Italy.
Giulia Costanza LeonardiDepartment of Biomedical and Biotechnological Sciences, Pathology and Oncology Section, University of Catania, Catania, Italy.
Boston Children's Hospital · USIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITOspedale Policlinico San Martino · ITUniversity of Catania · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of deep-sequencing methods is now unveiling a new landscape of previously undetected gene fusion across different tumor types. Chromosomal translocation involving the

Indexed as

chromosomal rearrangementslarotrectinibNTRKresistance

Identifiers

PMID31118670
PMCPMC6503327
OpenAlexW2942512225

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.