ArticleNeuropsychiatric disease and treatment2019
Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques.
Article in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Metabolomics in Depression: What We Learn from Preclinical and Clinical Evidences.Molecular neurobiology · 2025Pooled it
- Exploring the interplay between posttraumatic stress disorder, gut microbiota, and inflammatory biomarkers: a comprehensive meta-analysis.Frontiers in immunology · 2024Pooled it
- Pooled it
- The Role of Bacteria and Its Derived Metabolites in Chronic Pain and Depression: Recent Findings and Research Progress.The international journal of neuropsychopharmacology · 2020Pooled it
- Rifaximin Plus Probiotics Reshape Gut Microbiota, Serum Propionate, and Mucosal Immunity in Cirrhosis-Related Hepatic Encephalopathy Microbiota-Immune Remodeling in HE.Canadian journal of gastroenterology & hepatology · 2026Trial
- Inulin-type fructans and 2'fucosyllactose alter both microbial composition and appear to alleviate stress-induced mood state in a working population compared to placebo (maltodextrin): the EFFICAD Trial, a randomized, controlled trial.The American journal of clinical nutrition · 2023Trial
- Untargeted and Targeted Cerebrospinal Fluid Neurometabolomics via Chromatography-Mass Spectrometry-Based Methods.Molecules (Basel, Switzerland) · 2026Review
- Milk fat globule membrane ameliorates depressive-like behaviors in chronic unpredictable mild stress rats by modulating the microbiota-gut-brain axis.Bioscience of microbiota, food and health · 2026Article
- Microbiota and mycobiota in chronic inflammatory demyelinating polyneuropathy: clinical and pathophysiological correlations.Frontiers in molecular neuroscience · 2026Article
- Cognitive impairment in bipolar disorder associated with abnormal serum short-chain fatty acids and cytokines.BMC psychiatry · 2025Article
- Genetic and metabolic inflammation signatures in chronic inflammatory demyelinating polyneuropathy: the role ofFrontiers in molecular neuroscience · 2025Article
- Positioning berries in nutritional psychiatry: potential for prevention and co-therapy in mental health.Frontiers in behavioral neuroscience · 2025Article
- Exploring the microbiota-gut-brain axis: impact on brain structure and function.Frontiers in neuroanatomy · 2025Review
- Disrupted gut harmony in attention-deficit/hyperactivity disorder: Dysbiosis and decreased short-chain fatty acids.Brain, behavior, & immunity - health · 2024Article
- The Relationship between Canine Behavioral Disorders and Gut Microbiome and Future Therapeutic Perspectives.Animals : an open access journal from MDPI · 2024Review
- Gut microbiota connects the brain and the heart: potential mechanisms and clinical implications.Psychopharmacology · 2024Review
- Critical Factors in Sample Collection and Preparation for Clinical Metabolomics of Underexplored Biological Specimens.Metabolites · 2024Review
- Role of the gut microbiota in the pathogenesis of endometriosis: a review.Frontiers in microbiology · 2024Review
- Untargeted Metabolite Profiling of Adipose Tissue in Rats Exposed to Mepiquat.Foods (Basel, Switzerland) · 2023Article
- Thermal Stability of Fructooligosaccharides Extracted from Defatted Rice Bran: A Kinetic Study Using Liquid Chromatography-Tandem Mass Spectrometry.Foods (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDepression is a complex psychiatric disorder. Various depressive rodent models are usually constructed based on different pathogenesis hypotheses. MATERIALS AND
methodsHerein, using our previously established naturally occurring depressive (NOD) model in a non-human primate (cynomolgus monkey,
resultsTotally, 37 metabolites responsible for discriminating the two groups were identified. The NOD macaques were mainly characterized by perturbations of fatty acid biosynthesis, ABC transport system, and amino acid metabolism (eg, aspartate, glycine, serine, and threonine metabolism). Interestingly, we found that eight altered CSF metabolites belonging to short-chain fatty acids and amino acids were also observed in the serum of NOD macaques (N=13 per group).
conclusionOur findings suggest that peripheral and central short-chain fatty acids and amino acids are implicated in the onset of depression.
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