ArticleGenes and immunity2020
MiR-4295 facilitates cell proliferation and metastasis in head and neck squamous cell carcinoma by targeting NPTX1.
Article in Genes and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Expression Analysis of miRNA Profiles in Colorectal Cancer with a Bioinformatics Approach: An Emphasis on miR-4295, miR-4720-5p, miR-4773, and miR-6831-5p.Diagnostics (Basel, Switzerland) · 2026Article
- An integrative analysis of UFMylation-related genes reveals a prognostic signature and identifies GDF7 as a novel therapeutic target in gastric cancer.Frontiers in oncology · 2026Article
- m6A-mediated upregulation of miR-3690 drives HNSCC progression by regulating nuclear-cytoplasmic signaling pathway.Cellular and molecular life sciences : CMLS · 2025Article
- The LncRNA RMST-miR-4295-ITPR1 axis: a key mechanism in regulating autophagy in triple-negative breast cancer cells.BMC cancer · 2025Article
- miR-584-5p is a New Potential Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma.Current computer-aided drug design · 2025Article
- Unveiling miR-1468-5p: A New Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma.Recent patents on anti-cancer drug discovery · 2025Article
- Molecular characterization, clinical value, and cancer-immune interactions of genes related to disulfidptosis and ferroptosis in colorectal cancer.Discover oncology · 2024Article
- RNA-Based Liquid Biopsy in Head and Neck Cancer.Cells · 2023Review
- NPTX1 inhibits pancreatic cancer cell proliferation and migration and enhances chemotherapy sensitivity by targeting RBM10.Oncology letters · 2022Article
- The paradoxical roles of miR-4295 in human cancer: Implications in pathogenesis and personalized medicine.Genes & diseases · 2022Review
- MicroRNAs in head and neck squamous cell carcinoma: a possible challenge as biomarkers, determinants for the choice of therapy and targets for personalized molecular therapies.Translational cancer research · 2021Review
- Participation of MicroRNAs in the Treatment of Cancer with Phytochemicals.Molecules (Basel, Switzerland) · 2020Review
- Multivariate gene expression-based survival predictor model in esophageal adenocarcinoma.Thoracic cancer · 2020Article
- MicroRNA-3666 Suppresses Cell Growth in Head and Neck Squamous Cell Carcinoma Through Inhibition of PFKFB3-Mediated Warburg Effect.OncoTargets and therapy · 2020Article
- miR-762 Promotes Malignant Development of Head and Neck Squamous Cell Carcinoma by Targeting PHLPP2 and FOXO4.OncoTargets and therapy · 2019Article
- Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been reported that MicroRNAs (miRNAs) play pivotal roles in the occurrence and progression of a variety of cancers. As reported, miR-4295 promotes cell growth and metastasis in a lot of cancers. Nonetheless, the role and molecular mechanism of miR-4295 in HNSCC still remain unknown. In this study, we discovered miR-4295 expression was significantly upregulated in HNSCC tissues and cell lines, which is also associated with the overall survival of patients. Additionally, suppression of miR-4295 significantly inhibited cell proliferation, migration and EMT process in HNSCC. Through Targetscan website, it was predicted that NPTX1 might be a direct target gene of miR-4295. Then, we verified that NPTX1 could directly interact with miR-4295 via luciferase reporter and RNA assays. What's more, we discovered that there was a significantly negative correlation between NPTX1 and miR-4295 expression. It was indicated by further investigation that the effect of miR-4295 suppression on cell proliferation, migration and EMT process in HNSCC can be restored by knockdown of NPTX1 at the same time. Our results suggested that miR-4295 promoted the progression of HNSCC via regulating NPTX1 expression and miR-4295/NPTX1 axis, which may be a new therapeutic strategy for HNSCC.
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Registered trials
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