Evidence map›Paper›PMID 31118485›Full record

Trial reportScientific reports2019

Improving medication adherence in adult kidney transplantation (IMAKT): A pilot randomised controlled trial.

Jac Kee Low, Elizabeth Manias, Kimberley Crawford, Rowan Walker, William R Mulley, Nigel D Toussaint, Michael Dooley, Elaine Kennedy, Catherine L Smith, Michelle Nalder and 2 more

Open access · goldAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  7. Gender and kidney transplantation.Frontiers in nephrology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Jac Kee LowMonash Nursing & Midwifery, Monash University, Clayton, Victoria, Australia. jackee.low@gmail.com.ORCID http://orcid.org/0000-0002-7416-8645
Elizabeth ManiasSchool of Nursing and Midwifery, Centre for Quality and Patient Safety Research, Deakin University, Burwood, Victoria, Australia.
Kimberley CrawfordMonash Nursing & Midwifery, Monash University, Clayton, Victoria, Australia.
Rowan WalkerDepartment of Renal Medicine, Alfred Hospital, Melbourne, Victoria, Australia.
William R MulleyDepartment of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.
Nigel D ToussaintDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.
Michael DooleyAlfred Health, Prahran, Victoria, Australia.
Elaine KennedyDepartment of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.
Catherine L SmithSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Michelle NalderPharmacy Department, The Royal Melbourne Hospital, Parkville, Victoria, Australia.
Doris YipDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.
Allison WilliamsMonash Nursing & Midwifery, Monash University, Clayton, Victoria, Australia.
The Royal Melbourne Hospital · AUMonash University · AUMonash Medical Centre · AUAlfred Health · AUDeakin University · AUThe Alfred Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resources to support long-term medication adherence in kidney transplantation are limited. This study aimed to determine the efficacy of an intervention designed for kidney transplant recipients to enhance medication adherence. A single-blind, multi-site, 12-month pilot randomised controlled trial was conducted at all five public hospitals providing adult kidney transplantation in Victoria, Australia. Participants were recruited at 4 to 6 weeks post-transplantation. Thirty-five participants were randomly assigned to a 3-month intervention, involving a face-to-face meeting (a medication review and a consumer-centred video) and health coaching every two weeks. Thirty-six were randomised to receive usual care. All participants were followed for nine months post-intervention. There were no differences in adherence between groups measured by Medication Event Monitoring System (MEMS), however, it was underutilised by 42% of participants. Based on the self-reported Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS©) score, the percentage of adherent participants decreased significantly between baseline and 3 to 12 months in the control group (p-values < 0.001) whilst the percentage of adherent participants in the intervention group remained constant over time. No group differences were detected in other outcomes. Due to the complex medication regimen, developing and testing a medication adherence intervention is difficult in kidney transplantation.

Indexed as

Kidney TransplantationMedication AdherenceAdultAudiovisual AidsCounselingFemaleGraft RejectionHospitals, PublicHumansImmunosuppressive AgentsMaleMiddle AgedPatient Education as TopicPilot ProjectsSingle-Blind MethodTacrolimusImmunosuppressive AgentsTacrolimus

Identifiers

PMID31118485
PMCPMC6531445
OpenAlexW2946775979

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.