Evidence map›Paper›PMID 31118484›Full record

ArticleScientific reports2019

Staphylococcus aureus induces DNA damage in host cell.

Martine Deplanche, Nassim Mouhali, Minh-Thu Nguyen, Chantal Cauty, Frédéric Ezan, Alan Diot, Lesly Raulin, Stephanie Dutertre, Sophie Langouet, Patrick Legembre and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 41 citations in OpenAlex.

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  18. Skin Cancer-AssociatedCancers · 2022
    Article
  19. Transcriptome Architecture of Osteoblastic Cells Infected WithFrontiers in cellular and infection microbiology · 2022
    Article
  20. CanPolish journal of microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Martine DeplancheSTLO, INRA, Agrocampus Ouest, Rennes, France.
Nassim MouhaliSTLO, INRA, Agrocampus Ouest, Rennes, France.
Minh-Thu NguyenMicrobial Genetics, University of Tübingen, Tübingen, Germany.
Chantal CautySTLO, INRA, Agrocampus Ouest, Rennes, France.
Frédéric EzanUniv Rennes, Inserm, EHESP, Irset UMR_S 1085, F-35000, Rennes, France.
Alan DiotCentre International de Recherche en Infectiologie, INSERM U1111, CNRS, Université Lyon 1, Lyon, France.
Lesly RaulinCNRS, Inserm, BIOSIT-UMS 3480, MRic, Université de Rennes, Rennes, France.
Stephanie DutertreCNRS, Inserm, BIOSIT-UMS 3480, MRic, Université de Rennes, Rennes, France.
Sophie LangouetUniv Rennes, Inserm, EHESP, Irset UMR_S 1085, F-35000, Rennes, France.
Patrick LegembreCentre Eugène Marquis, Equipe Ligue Contre Le Cancer, Rennes, France.
Frederic TaiebIRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France.
Michael OttoLaboratory of Human Bacterial Pathogenesis, US National Institutes of Health, Bethesda, Maryland, 20892, USA.ORCID http://orcid.org/0000-0002-2222-4115
Frédéric LaurentCentre International de Recherche en Infectiologie, INSERM U1111, CNRS, Université Lyon 1, Lyon, France.
Friedrich GötzMicrobial Genetics, University of Tübingen, Tübingen, Germany.
Yves Le LoirSTLO, INRA, Agrocampus Ouest, Rennes, France.ORCID http://orcid.org/0000-0002-0355-1065
Nadia BerkovaSTLO, INRA, Agrocampus Ouest, Rennes, France. nadejda.berkova@inra.fr.ORCID http://orcid.org/0000-0001-6246-5549
Institut Agro Rennes-Angers · FRCentre National de la Recherche Scientifique · FRInserm · FRUniversité Claude Bernard Lyon 1 · FRUniversity of Tübingen · DECentre Eugène Marquis · FRNational Institutes of Health · USUniversité Toulouse III - Paul Sabatier · FR

Funding

Staphylococcal pathogenesisZIAAI000904 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI OTTO, MICHAEL · 2009 to 2025
$22.6M
Intramural NIH HHS ZIA AI000904
6 · The paper itself

Abstract

Staphylococcus aureus causes serious medical problems in human and animals. Here we show that S. aureus can compromise host genomic integrity as indicated by bacteria-induced histone H2AX phosphorylation, a marker of DNA double strand breaks (DSBs), in human cervix cancer HeLa and osteoblast-like MG-63 cells. This DNA damage is mediated by alpha phenol-soluble modulins (PSMα

Indexed as

DNA DamageAcetylcysteineArthritis, InfectiousBacterial ToxinsCell Line, TumorDNA RepairEtoposideG2 Phase Cell Cycle CheckpointsGenomic IslandsGuanineHeLa CellsHistonesHost-Pathogen InteractionsHumansLipoproteinsOsteitis8-hydroxyguanineAcetylcysteineBacterial ToxinsEtoposideGuanineH2AX protein, humanHistonesLipoproteinsReactive Oxygen Speciesstaphylococcal delta toxin

Identifiers

PMID31118484
PMCPMC6531466
OpenAlexW2947242568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.