Evidence map›Paper›PMID 31118448›Full record

ArticleNature communications2019

Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4

Kim-Long Truong, Stephan Schlickeiser, Katrin Vogt, David Boës, Katarina Stanko, Christine Appelt, Mathias Streitz, Gerald Grütz, Nadja Stobutzki, Christian Meisel and 9 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 112 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Gliadin-specific CD4Science advances · 2026
    Article
  4. The CX3CL1-CX3CR1 axis in HIV-associated inflammation and cardiometabolic disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Review
  5. Cell surface ADGRG1 and CD86 expression identifies antitumor CD4Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Transcriptional landscape of CD4+ T cells in Systemic Sclerosis.bioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Article
  13. Early-life human CD8Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 1 country.

Kim-Long TruongInstitute of Medical Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 13353, Berlin, Germany.
Stephan SchlickeiserInstitute of Medical Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 13353, Berlin, Germany.
Katrin VogtInstitute of Medical Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 13353, Berlin, Germany.
David BoësInstitute of Medical Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 13353, Berlin, Germany.
Katarina StankoInstitute of Medical Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 13353, Berlin, Germany.
Christine AppeltInstitute of Medical Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 13353, Berlin, Germany.
Mathias StreitzInstitute of Medical Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 13353, Berlin, Germany.
Gerald GrützInstitute of Medical Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 13353, Berlin, Germany.
Nadja StobutzkiInstitute of Medical Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 13353, Berlin, Germany.
Christian MeiselInstitute of Medical Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 13353, Berlin, Germany.
Christina IwertInstitute of Medical Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 13353, Berlin, Germany.
Stefan TomiukMilteny Biotec GmbH, 51429, Bergisch Gladbach, Germany.
Julia K PolanskyBerlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.
Andreas PascherDepartment of Surgery, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.
Nina BabelBerlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.
Ulrik StervboMedical Clinic I, Marien Hospital Herne, University Clinic of Ruhr-University Bochum, 44625, Herne, Germany.ORCID http://orcid.org/0000-0002-2831-8868
Igor SauerDepartment of Surgery, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.ORCID http://orcid.org/0000-0001-9355-937X
Undine GerlachDepartment of Surgery, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.
Birgit SawitzkiInstitute of Medical Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 13353, Berlin, Germany. birgit.sawitzki@charite.de.
Humboldt-Universität zu Berlin · DECharité - Universitätsmedizin Berlin · DEUniversitätsklinik Marien Hospital Herne · DEGerman Rheumatism Research Centre · DEMiltenyi Biotec (Germany) · DE

Funding

Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie (Federal Ministry for Education, Science, Research and Technology) e:kidBundesministerium für Bildung, Wissenschaft und Kultur (Federal Ministry of Education, Science and Culture) e:KidDeutsche Forschungsgemeinschaft (German Research Foundation) SFB650
6 · The paper itself

Abstract

All memory T cells mount an accelerated response on antigen reencounter, but significant functional heterogeneity is present within the respective memory T-cell subsets as defined by CCR7 and CD45RA expression, thereby warranting further stratification. Here we show that several surface markers, including KLRB1, KLRG1, GPR56, and KLRF1, help define low, high, or exhausted cytokine producers within human peripheral and intrahepatic CD4

Indexed as

AgedAged, 80 and overCD4-Positive T-LymphocytesCytokinesHumansImmunologic MemoryLiverLiver DiseasesMiddle AgedReceptors, G-Protein-CoupledReceptors, NK Cell Lectin-LikeADGRG1 protein, humanCytokinesReceptors, G-Protein-CoupledReceptors, NK Cell Lectin-Like

Identifiers

PMID31118448
PMCPMC6531457
OpenAlexW2944948027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.