Evidence map›Paper›PMID 31118442›Full record

ArticleScientific reports2019

Differential Immune Activation in Fetal Macrophage Populations.

Omar Lakhdari, Asami Yamamura, Gilberto E Hernandez, Kathryn K Anderson, Sean J Lund, Gertrude O Oppong-Nonterah, Hal M Hoffman, Lawrence S Prince

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Regulation of oral antigen delivery early in life: Implications for oral tolerance and food allergy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Omar LakhdariDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, Rady Children's Hospital, San Diego, San Diego, CA, USA.
Asami YamamuraDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, Rady Children's Hospital, San Diego, San Diego, CA, USA.
Gilberto E HernandezDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, Rady Children's Hospital, San Diego, San Diego, CA, USA.
Kathryn K AndersonDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, Rady Children's Hospital, San Diego, San Diego, CA, USA.
Sean J LundDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, Rady Children's Hospital, San Diego, San Diego, CA, USA.
Gertrude O Oppong-NonterahDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, Rady Children's Hospital, San Diego, San Diego, CA, USA.
Hal M HoffmanDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, Rady Children's Hospital, San Diego, San Diego, CA, USA.
Lawrence S PrinceDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, Rady Children's Hospital, San Diego, San Diego, CA, USA. lprinceucsd@gmail.com.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
Innate Immune Activation and Endothelial Cell Dysfunction in Acute Kawasaki DiseaseR01HL140898 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURNS, JANE C, HOFFMAN, HAROLD M · 2018 to 2022
$4.3M
FGF-10 Expression in a Fetal Mouse Lung Model of Bronchopulmonary DysplasiaR01HL086324 · NHLBI · VANDERBILT UNIVERSITY · PI PRINCE, LAWRENCE S · 2008 to 2017
$3.7M
Role of Fetal Lung Macrophages in Broncopulmonary DysplasiaR01HL097195 · NHLBI · VANDERBILT UNIVERSITY · PI BLACKWELL, TIMOTHY S., PRINCE, LAWRENCE S · 2009 to 2013
$2.6M
Transcriptional Control of Lung Macrophage DevelopmentR01HL126703 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOFFMAN, HAROLD M, PRINCE, LAWRENCE S · 2015 to 2018
$1.6M
Glycan-Lectin Receptor Regulation of Macrophage Maturation and Lung InnateDefenses in the Fetus and Newborn InfantR01AI142864 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR, PRINCE, LAWRENCE S · 2019 to 2021
$1.2M
NCATS NIH HHS UL1 TR001442NHLBI NIH HHS R01 HL086324NHLBI NIH HHS R01 HL097195NHLBI NIH HHS R01 HL126703NHLBI NIH HHS R01 HL140898NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI142864
6 · The paper itself

Abstract

Distinct macrophage subsets populate the developing embryo and fetus in distinct waves. However little is known about the functional differences between in utero macrophage populations or how they might contribute to fetal and neonatal immunity. Here we tested the innate immune response of mouse macrophages derived from the embryonic yolk sac and from fetal liver. When isolated from liver or lung, CD11b

Indexed as

AnimalsCytokinesFetusGene Expression ProfilingImmunity, InnateInflammasomesInflammationLipopolysaccharidesLiverMacrophage ActivationMacrophagesMiceMice, Inbred C57BLNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinOrgan SpecificityCytokinesInflammasomeslipopolysaccharide, E coli O55-B5LipopolysaccharidesNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseTlr4 protein, mouseToll-Like Receptor 4

Identifiers

PMID31118442
PMCPMC6531440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.