Evidence map›Paper›PMID 31118423›Full record

ArticleNature communications2019

Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis.

Edgar-John Vogt, Keizo Tokuhiro, Min Guo, Ryan Dale, Guanghui Yang, Seung-Wook Shin, Maria Jimenez Movilla, Hari Shroff, Jurrien Dean

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 41 citations in OpenAlex.

  1. Effect of Anti-Müllerian Hormone on Oocytes In Vitro Maturation in Sheep.International journal of molecular sciences · 2026
    Article
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  10. The TRPV3 channel is a mediator of zinc influx and homeostasis in murine oocytes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Review
  12. Effects of pentoxifylline on mouse oocytes maturation and qualityIranian journal of basic medical sciences · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Edgar-John VogtLaboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD, 20892, USA.
Keizo TokuhiroLaboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD, 20892, USA.
Min GuoSection on High Resolution Optical Imaging, NIBIB, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-2093-8771
Ryan DaleLaboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD, 20892, USA.
Guanghui YangLaboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD, 20892, USA.
Seung-Wook ShinLaboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD, 20892, USA.
Maria Jimenez MovillaDepartment of Cell Biology and Histology, Medical School, University of Murcia, IMIB, 30100, Murcia, Spain.ORCID http://orcid.org/0000-0002-1572-8219
Hari ShroffSection on High Resolution Optical Imaging, NIBIB, National Institutes of Health, Bethesda, MD, 20892, USA.
Jurrien DeanLaboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD, 20892, USA. jurrien.dean@nih.gov.ORCID http://orcid.org/0000-0002-7127-0871
National Institutes of Health · USKansai Medical University · JPUniversidad de Murcia · ES

Funding

Molecular Biology of the OocyteZIADK015603 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI DEAN, JURRIEN · 2009 to 2025
$43.2M
NICHD Bioinformatics and Scientific Programming CoreZICHD008986 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI DALE, RYAN · 2019 to 2025
$17.4M
Section on High Resolution Optical ImagingZIAEB000074 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI SHROFF, HARI · 2010 to 2022
$15.2M
Intramural NIH HHS ZIA DK015603U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1 ZIA DK015603 12
6 · The paper itself

Abstract

Following fertilization, cortical granules exocytose ovastacin, a metalloendopeptidase that cleaves ZP2 in the zona pellucida surrounding mouse eggs to prevent additional sperm binding. Using high- and super-resolution imaging with ovastacin

Indexed as

AnimalsAntigensCell MembraneCytoplasmic GranulesEgg ProteinsExocytosisFemaleIntravital MicroscopyLuminescent ProteinsMaleMetalloproteasesMiceMice, TransgenicMicroscopy, FluorescenceRed Fluorescent ProteinSperm-Ovum InteractionsAntigensAstl protein, mouseEgg ProteinsLuminescent ProteinsMetalloproteasesNalp5 protein, mouseRed Fluorescent ProteinZona Pellucida GlycoproteinsZp2 protein, mouse

Identifiers

PMID31118423
PMCPMC6531442
OpenAlexW2945841572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.