ArticleScience translational medicine2019
Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium.
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 94 citations in OpenAlex.
- Topical vascular organoid therapy promotes microvascular regeneration and functional recovery in porcine ischemic cardiomyopathy.Stem cell reports · 2026Article
- Engineered ATP-loaded extracellular vesicles: a dual-functional strategy for improving myocardial infarction therapy.Drug delivery and translational research · 2026Article
- Genetically engineered senescence-resistant human mesenchymal progenitor cells promote spinal cord injury repair.Life medicine · 2026Article
- Rapid manufacturing of angiogenic cellular collagen patches for ischemic cardiomyopathy.Stem cells translational medicine · 2025Article
- Hypoxic Neural Stem Cells Enhance Spinal Cord Repair Through HIF-1a/RAB17-Driven Extracellular Vesicle Release.Journal of extracellular vesicles · 2025Article
- Minimally invasive snakebite inspired microneedle delivery system for internal organs.Bioactive materials · 2025Article
- Exosomal Biomarkers: A Comprehensive Overview of Diagnostic and Prognostic Applications in Malignant and Non-Malignant Disorders.Biomolecules · 2025Review
- Programmable production of bioactive extracellular vesicles in vivo to treat myocardial infarction.Nature communications · 2025Article
- Transcriptomic analysis of circulating extracellular vesicles during the perioperative period of Fontan and Glenn surgery.NPJ cardiovascular health · 2024Article
- Emerging role of sphingolipids and extracellular vesicles in development and therapeutics of cardiovascular diseases.International journal of cardiology. Heart & vasculature · 2024Review
- Adult cardiomyocytes-derived EVs for the treatment of cardiac fibrosis.Journal of extracellular vesicles · 2024Article
- Comparison of the efficiency of ultrafiltration, precipitation, and ultracentrifugation methods for exosome isolation.Biochemistry and biophysics reports · 2024Article
- Endothelial progenitor cell-derived extracellular vesicles: the world of potential prospects for the treatment of cardiovascular diseases.Cell & bioscience · 2024Review
- Regulation of cardiac fibroblasts reprogramming into cardiomyocyte-like cells with a cocktail of small molecule compounds.FEBS open bio · 2024Article
- The Effect of Parent Cell Type on Small Extracellular Vesicle-Derived Vehicle Functionality.Advanced biology · 2024Article
- Statistical modeling of extracellular vesicle cargo to predict clinical trial outcomes for hypoplastic left heart syndrome.iScience · 2023Article
- The role of miR1 and miR133a in new-onset atrial fibrillation after acute myocardial infarction.BMC cardiovascular disorders · 2023Article
- Regeneration of the heart: from molecular mechanisms to clinical therapeutics.Military Medical Research · 2023Review
- Review
- Knockdown of deleterious miRNA in progenitor cell-derived small extracellular vesicles enhances tissue repair in myocardial infarction.Science advances · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 3 institutions in 1 country.
Progyaparamita SahaDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-0248-3531
Sudhish SharmaDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Laxminarayana KorutlaDivision of Cardiovascular Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
Srinivasa Raju DatlaDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Farnaz Shoja-TaheriWallace H. Coulter Department of Biomedical Engineering and Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0003-3939-6674
Rachana MishraDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Grace E BighamDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Malini SarkarDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-1013-5841
David MoralesDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-3751-4614
Gregory BittleDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Muthukumar GunasekaranDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Chetan AmbasthaDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Mir Yasir ArfatDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Deqiang LiDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Andreas HabertheuerDivision of Cardiovascular Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
Robert HuDivision of Cardiovascular Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
Manu O PlattWallace H. Coulter Department of Biomedical Engineering and Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0001-6390-4320
Peixin YangDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Michael E DavisWallace H. Coulter Department of Biomedical Engineering and Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Prashanth VallabhajosyulaDivision of Cardiovascular Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA. skaushal@smail.umaryland.edu prashanth.vallabhajosyula@uphs.upenn.edu.
Sunjay KaushalDivision of Cardiovascular Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA. skaushal@smail.umaryland.edu prashanth.vallabhajosyula@uphs.upenn.edu.ORCID 0000-0002-0511-9997
University of Maryland, Baltimore · USUniversity of Pennsylvania · USThe Wallace H. Coulter Department of Biomedical Engineering · US
Funding
Interdisciplinary Training Program Muscle BiologyT32AR007592 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Aikaterini Kontrogianni-Konstantopoulos · 1996 to 2026
$11.7MMechanism of transplanted neonatal cardiac progenitor cells to repair ischemic myocardiumR01HL118491 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SCHUMACKER, PAUL T · 2014 to 2024
$4.4MPredictive and systems modeling of exosome cargoR01HL145644 · NHLBI · EMORY UNIVERSITY · PI DAVIS, MICHAEL E · 2019 to 2022
$3.1MCharacterization of the Cardiac Progenitor Cell Exosomes for Optimal TherapeuticsR01HL141922 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI KAUSHAL, SUNJAY · 2019 to 2022
$2.8MMicroRNA-Suppressed Mitochondrial Fusion in Mediating the Teratogenicity of Maternal Diabetes Leading to Heart DefectsR01HL134368 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI WANG, JIAN-YING, YANG, PEIXIN · 2017 to 2020
$2.4MThe Role of C-Kit Positive Cardiac Progenitors in Maternal Diabetes-Induced Heart Defects and the Therapeutic Values of These CellsR01HL139060 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI KAUSHAL, SUNJAY, YANG, PEIXIN · 2017 to 2020
$2.4MNHLBI NIH HHS R01 HL118491NHLBI NIH HHS R01 HL139060NHLBI NIH HHS R01 HL141922NHLBI NIH HHS R01 HL145644NIAMS NIH HHS T32 AR007592
Abstract
The stem cell field is hindered by its inability to noninvasively monitor transplanted cells within the target organ in a repeatable, time-sensitive, and condition-specific manner. We hypothesized that quantifying and characterizing transplanted cell-derived exosomes in the recipient plasma would enable reliable, noninvasive surveillance of the conditional activity of the transplanted cells. To test this hypothesis, we used a human-into-rat xenogeneic myocardial infarction model comparing two well-studied progenitor cell types: cardiosphere-derived cells (CDCs) and c-kit
Indexed as
Recovery of FunctionStem Cell TransplantationAgedAnimalsExosomesFemaleHumansMajor Histocompatibility ComplexMaleMicroRNAsMyocardial IschemiaMyocytes, CardiacPhenotypeProto-Oncogene Proteins c-kitRats, NudeReproducibility of ResultsMicroRNAsProto-Oncogene Proteins c-kit
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.