Trial reportScience translational medicine2019
Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection.
Open access · greenAbstract readClinical Trial
In one paragraph
Trial report in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 86 citations in OpenAlex.
- Trial
- Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection.The Journal of infectious diseases · 2022Trial
- Early intervention, lasting impact: benefits of early antiretroviral therapy and implications for posttreatment control.Current opinion in HIV and AIDS · 2026Review
- Duration of Initial Viremia Modulates Functional Properties of HIV-specific T Cell Receptors.Research square · 2026Article
- Duration of Initial Viremia Modulates Functional Properties of HIV-specific T Cell Receptors.bioRxiv : the preprint server for biology · 2026Article
- CD8Nature · 2026Article
- Article
- CD8medRxiv : the preprint server for health sciences · 2025Article
- Current insight into HIV-1 persistence from single-cell transcriptome profiling in acutely treated cohorts of infection.Current opinion in HIV and AIDS · 2025Review
- Autovaccination revisited: potential to boost antiviral immunity and facilitate HIV-1 cure/remission in children.Current opinion in HIV and AIDS · 2025Review
- Early treatment and PD1 inhibition enhance HIV-specific functionality of follicular CD8+ T cells.JCI insight · 2025Article
- Acute HIV-1 Infection: Paradigm and Singularity.Viruses · 2025Review
- Article
- HIV cure research contributions from Africa in the last three decades.Frontiers in immunology · 2025Review
- Dynamics of the blood plasma proteome during hyperacute HIV-1 infection.Nature communications · 2024Article
- Footprints of innate immune activity during HIV-1 reservoir cell evolution in early-treated infection.The Journal of experimental medicine · 2024Article
- Review
- Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection.medRxiv : the preprint server for health sciences · 2024Article
- HIV Expression in Infected T Cell Clones.Viruses · 2024Review
- Broadly neutralizing antibodies targeting HIV: Progress and challenges.Clinical immunology (Orlando, Fla.) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 3 countries.
Zaza M NdhlovuAfrica Health Research Institute, 4036 Durban, South Africa. zndhlovu@mgh.harvard.edu bwalker@mgh.harvard.edu.ORCID 0000-0002-2708-3315
Samuel W KazerRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.ORCID 0000-0002-7380-9594
Thandeka NkosiAfrica Health Research Institute, 4036 Durban, South Africa.ORCID 0000-0002-9516-3835
Funsho OgunsholaAfrica Health Research Institute, 4036 Durban, South Africa.ORCID 0000-0002-5655-4905
Daniel M MuemaAfrica Health Research Institute, 4036 Durban, South Africa.ORCID 0000-0001-7995-1682
Gursev AnmoleDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.ORCID 0000-0001-6747-1315
Shayda A SwannFaculty of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Amber MoodleyHIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, 4013 Durban, South Africa.ORCID 0000-0003-3409-3244
Krista DongRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.ORCID 0000-0002-2038-3518
Tarylee ReddySouth Africa Medical Research Council, 4091 Durban, South Africa.ORCID 0000-0002-9521-2692
Mark A BrockmanDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.ORCID 0000-0001-6432-1426
Alex K ShalekRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.ORCID 0000-0001-5670-8778
Thumbi Ndung'uAfrica Health Research Institute, 4036 Durban, South Africa.ORCID 0000-0003-2962-3992
Bruce D WalkerRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. zndhlovu@mgh.harvard.edu bwalker@mgh.harvard.edu.ORCID 0000-0001-6122-9245
Centre for the AIDS Programme of Research in South Africa · ZABroad Institute · USSimon Fraser University · CAAfrica Health Research Institute · ZAHoward Hughes Medical Institute · USRagon Institute of MGH, MIT and Harvard · USSouth African Medical Research Council · ZA
Funding
The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4MRole of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI David A. Hafler · 1996 to 2026
$51.7MSystems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI David A. Hafler, RUTH R MONTGOMERY · 2010 to 2026
$50.4MBELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral EradicationUM1AI126617 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JONES, R. BRAD, NIXON, DOUGLAS F · 2016 to 2020
$28.1MCenter for Cell CircuitsRM1HG006193 · NHGRI · BROAD INSTITUTE, INC. · PI BLAINEY, PAUL CLARK, HACOHEN, NIR · 2016 to 2020
$14.9MNovel Biologic Therapies for GVHDR01HL095791 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI KEAN, LESLIE S · 2010 to 2025
$13.3MQuantitative and functional characterization of therapeutic resistance in cancerU54CA217377 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MANALIS, SCOTT R · 2017 to 2021
$10.2MPathogenesis of Clade C HIV InfectionR37AI067073 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI WALKER, BRUCE D · 2011 to 2020
$6.6MA systems biology approach to fingerprint HIV immune defense in Elite ControllersR01HL134539 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI YU, XU · 2016 to 2019
$3.3MAn integrated multiplexed genomic assay for low input clinical samples1U24AI118672 · NIAID · BROAD INSTITUTE, INC. · PI SHALEK, ALEX K · 2015 to 2019
$2.0MClinical implementation of single cell tumor transcriptome analysisR33CA202820 · NCI · BROAD INSTITUTE, INC. · PI GOLUB, TODD R., JOHNSON, BRUCE E. · 2016 to 2018
$1.3MEpigenetic Control of CD8 T-Cell Differentiation in Human Lymph NodesR01AI145305 · NIAID · KWAZULU-NATAL RESEARCH INSTITUTE TB-HIV · PI NDHLOVU, ZAZA MTINE · 2019 to 2023
$715kHoward Hughes Medical Institute 55008743NCI NIH HHS R33 CA202820NCI NIH HHS U54 CA217377NHGRI NIH HHS RM1 HG006193NHLBI NIH HHS R01 HL095791NHLBI NIH HHS R01 HL134539NIAID NIH HHS P01 AI039671NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI145305NIAID NIH HHS R37 AI067073NIAID NIH HHS U19 AI089992NIAID NIH HHS U24 AI118672NIAID NIH HHS UM1 AI126617
Abstract
Sustained viremia after acute HIV infection is associated with profound CD4
Indexed as
Acute DiseaseAdolescentAntigens, ViralAnti-Retroviral AgentsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCell ProliferationDrug Therapy, CombinationHIV-1HIV InfectionsHumansImmunologic MemoryInterferon-gammaInterleukin-7 Receptor alpha SubunitPhenotypeAntigens, ViralAnti-Retroviral AgentsInterferon-gammaInterleukin-7 Receptor alpha Subunit
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.