ArticleJournal of virology2019
Infectious Virus Persists in CD4
Open access · hybridAbstract read
In one paragraph
Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 68 citations in OpenAlex.
- Monocytes across life span in HIV infection: lights and shadows.Current opinion in HIV and AIDS · 2025Review
- Immune Alterations and Viral Reservoir Atlas in SIV-Infected Chinese Rhesus Macaques.Infectious disease reports · 2025Review
- Intact HIV Reservoir in Monocytes Is Associated With Cognitive Function in Virally Suppressed Women With HIV.The Journal of infectious diseases · 2025Article
- Article
- HIV-1 Myeloid Reservoirs - Contributors to Viral Persistence and Pathogenesis.Current HIV/AIDS reports · 2024Review
- Quantitative and Qualitative Distinctions between HIV-1 and SIV Reservoirs: Implications for HIV-1 Cure-Related Studies.Viruses · 2024Review
- Opioid abuse and SIV infection in non-human primates.Journal of neurovirology · 2023Review
- Early ART reduces viral seeding and innate immunity in liver and lungs of SIV-infected macaques.JCI insight · 2023Article
- Article
- Monocyte-derived macrophages contain persistent latent HIV reservoirs.Nature microbiology · 2023Article
- RNA landscapes of brain tissue and brain tissue-derived extracellular vesicles in simian immunodeficiency virus (SIV) infection and SIV-related central nervous system pathology.bioRxiv : the preprint server for biology · 2023Article
- In vivo killing of primary HIV-infected cells by peripheral-injected early memory-enriched anti-HIV duoCAR T cells.JCI insight · 2022Article
- HIV-1-induced type I IFNs promote viral latency in macrophages.Journal of leukocyte biology · 2022Article
- Antiretroviral therapy restores the homeostatic state of microglia in SIV-infected rhesus macaques.Journal of leukocyte biology · 2022Article
- Article
- Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP.Retrovirology · 2022Article
- Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates.Antimicrobial agents and chemotherapy · 2022Article
- Allogeneic MHC-matched T-cell receptor α/β-depleted bone marrow transplants in SHIV-infected, ART-suppressed Mauritian cynomolgus macaques.Scientific reports · 2022Article
- Repression of HIV-1 reactivation mediated by CRISPR/dCas9-KRAB in lymphoid and myeloid cell models.Retrovirology · 2022Article
- HIV-1 cell-to-cell spread overcomes the virus entry block of non-macrophage-tropic strains in macrophages.PLoS pathogens · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Celina M AbreuDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-0889-1384
Rebecca T VeenhuisDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Claudia R AvalosDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Shelby GrahamDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Suzanne E QueenDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Erin N ShirkDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Brandon T BullockDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ming LiDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kelly A Metcalf PateDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-4799-4631
Sarah E BeckDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Lisa M MangusDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Joseph L MankowskiDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Janice E ClementsDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Lucio GamaDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA lucio@jhmi.edu.
Johns Hopkins University · US
Funding
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0MProject 4: Intracellular mechanism of virus persistence in astrocytes/macrophagesP01MH070306 · NIMH · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E · 2004 to 2015
$16.0MViral Testing CoreU42OD013117 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2017 to 2026
$10.9MDevelopment of an SPF Macaca nemestrina Breeding ColonyP40OD013117 · OD · JOHNS HOPKINS UNIVERSITY · PI ADAMS, ROBERT J. · 2012 to 2016
$4.9MMacrophage Ontogeny and Polarization in HIV/SIV InfectionR01AI127142 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E, GAMA, LUCIO · 2016 to 2020
$3.8MNovel SIV Model of HANDR01NS077869 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E, MANKOWSKI, JOSEPH L · 2012 to 2016
$3.8MPlasma miRNA Biomarkers of HIV/SIV CNS DiseaseR01NS076357 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E · 2012 to 2016
$2.7MMacrophage Polarization in SIV Infection and LatencyR56AI118753 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E · 2015 to 2015
$773kVirus like particles as a therapeutic vaccine for HIVK01OD021323 · OD · JOHNS HOPKINS UNIVERSITY · PI BECK, SARAH · 2016 to 2020
$651kNIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI127142NIAID NIH HHS R56 AI118753NIH HHS K01 OD021323NIH HHS P40 OD013117NIH HHS U42 OD013117NIMH NIH HHS P01 MH070306NINDS NIH HHS R01 NS076357NINDS NIH HHS R01 NS077869
Abstract
Understanding the cellular and anatomical sites of latent virus that contribute to human immunodeficiency virus (HIV) rebound is essential for eradication. In HIV-positive patients, CD4
Indexed as
Virus LatencyAnimalsAnti-Retroviral AgentsBlood CellsCD4-Positive T-LymphocytesCells, CulturedLungMacacaMacrophagesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusSpleenAnti-Retroviral AgentsCD4+ T cellslatencymacrophagesquantitative viral outgrowth assayreservoirsimian immunodeficiency virus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.