Evidence map›Paper›PMID 31118223›Full record

ArticleThe Journal of biological chemistry2019

The structural unit of melanin in the cell wall of the fungal pathogen

Emma Camacho, Raghav Vij, Christine Chrissian, Rafael Prados-Rosales, David Gil, Robert N O'Meally, Radames J B Cordero, Robert N Cole, J Michael McCaffery, Ruth E Stark and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 126 citations in OpenAlex.

  1. Article
  2. Dismantling darkness: interdisciplinary perspectives on melanin degradation.World journal of microbiology & biotechnology · 2026
    Review
  3. Article
  4. Review
  5. Solid-state NMR spectroscopy reveals unique properties ofCell surface (Amsterdam, Netherlands) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. α-glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Insights from Mass Spectrometry-Based Proteomics onJournal of fungi (Basel, Switzerland) · 2025
    Review
  13. Article
  14. Review
  15. mSphere · 2025
    Article
  16. Review
  17. Article
  18. Regulation of melanin production in fungi.Frontiers in fungal biology · 2025
    Review
  19. Article
  20. Cell wall melanin impedes growth of theProceedings of the National Academy of Sciences of the United States of America · 2024
    Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Emma CamachoFrom the Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205.ORCID 0000-0001-8591-8176
Raghav VijFrom the Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205.ORCID 0000-0001-5812-0484
Christine Chrissianthe Department of Chemistry and Biochemistry, City College of New York and CUNY Institute for Macromolecular Assemblies, New York, New York 10031, the City University of New York.ORCID 0000-0003-2858-4864
Rafael Prados-Rosalesthe Department of Microbiology and Immunology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461.ORCID 0000-0001-5964-0166
David Gilthe CIC bioGUNE, 48160 Derio, Vizcaya, Spain.ORCID 0000-0003-4241-1302
Robert N O'Meallythe Johns Hopkins Mass Spectrometry and Proteomic Facility, The Johns Hopkins University, Baltimore, Maryland 21205, and.
Radames J B CorderoFrom the Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205.ORCID 0000-0002-3026-7094
Robert N Colethe Johns Hopkins Mass Spectrometry and Proteomic Facility, The Johns Hopkins University, Baltimore, Maryland 21205, and.ORCID 0000-0002-3096-4754
J Michael McCafferythe Integrated Imaging Center, Department of Biology, Engineering in Oncology Center, and Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, Maryland 21218.
Ruth E Starkthe Department of Chemistry and Biochemistry, City College of New York and CUNY Institute for Macromolecular Assemblies, New York, New York 10031, the City University of New York.ORCID 0000-0002-3132-4580
Arturo CasadevallFrom the Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, acasade1@jhu.edu.ORCID 0000-0002-9402-9167
Johns Hopkins University · USCity College of New York · USAlbert Einstein College of Medicine · USCIC bioGUNE · ES

Funding

Cellular/Molecular Basis of Development: Research CenterG12MD007603 · NIMHD · CITY COLLEGE OF NEW YORK · PI PEZZANO, MARK · 2012 to 2017
$11.5M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
NIAID NIH HHS R01 AI052733NIMHD NIH HHS G12 MD007603
6 · The paper itself

Abstract

Melanins are synthesized macromolecules that are found in all biological kingdoms. These pigments have a myriad of roles that range from microbial virulence to key components of the innate immune response in invertebrates. Melanins also exhibit unique properties with potential applications in physics and material sciences, ranging from electrical batteries to novel therapeutics. In the fungi, melanins, such as eumelanins, are components of the cell wall that provide protection against biotic and abiotic elements. Elucidation of the smallest fungal cell wall-associated melanin unit that serves as a building block is critical to understand the architecture of these polymers, its interaction with surrounding components, and their functional versatility. In this study, we used isopycnic gradient sedimentation, NMR, EPR, high-resolution microscopy, and proteomics to analyze the melanin in the cell wall of the human pathogenic fungus

Indexed as

Cell WallCryptococcus neoformansLevodopaMagnetic Resonance SpectroscopyMelaninsMicroscopy, Electron, TransmissionNanoparticlesParticle SizePhylogenyProteomicsLevodopaMelaninsbasic unitbiopolymercell wallcryo-electron microscopyfungimelaninmelanogenesismelanosomessolid-state NMRsupramolecular structure

Identifiers

PMID31118223
PMCPMC6615676
OpenAlexW2946276259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.