ArticleThe Journal of pharmacology and experimental therapeutics2019
Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury.
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Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
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18 citing papers in PubMed, 29 citations in OpenAlex.
- Anatomical Identification and Pressure Myography of the Rat Middle Cerebral Artery: A Comprehensive Protocol for Diverse Genetic Models.bioRxiv : the preprint server for biology · 2026Article
- Gene modification: Exploring the potential in treating kidney diseases.Pharmacological research · 2026Review
- Beyond Blood Pressure: Emerging Pathways and Precision Approaches in Hypertension-Induced Kidney Damage.International journal of molecular sciences · 2025Review
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- Role ofbioRxiv : the preprint server for biology · 2023Article
- Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling.iScience · 2023Article
- Longitudinal characterization of cerebral hemodynamics in the TgF344-AD rat model of Alzheimer's disease.GeroScience · 2023Article
- Enhanced Cerebral Hemodynamics and Cognitive Function Via Knockout of Dual-Specificity Protein Phosphatase 5.Journal of pharmacy and pharmacology research · 2023Article
- Luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, reverses cerebrovascular dysfunction and cognitive impairments in 18-mo-old diabetic animals.American journal of physiology. Heart and circulatory physiology · 2022Article
- The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension-vascular, renal, and cognitive diseases.Physiological genomics · 2022Review
- Dual-Specificity Phosphatases and Kidney Diseases.Kidney diseases (Basel, Switzerland) · 2022Review
- Knockout ofThe Journal of pharmacology and experimental therapeutics · 2021Article
- Genetic susceptibility of hypertension-induced kidney disease.Physiological reports · 2021Review
- Role of γ-adducin in actin cytoskeleton rearrangements in podocyte pathophysiology.American journal of physiology. Renal physiology · 2021Article
- Altered renal hemodynamics is associated with glomerular lipid accumulation in obese Dahl salt-sensitive leptin receptor mutant rats.American journal of physiology. Renal physiology · 2020Article
- A Mutation inJournal of the American Society of Nephrology : JASN · 2020Article
- Influence of dual-specificity protein phosphatase 5 on mechanical properties of rat cerebral and renal arterioles.Physiological reports · 2020Article
- Endoplasmic Reticulum Stress Increases DUSP5 Expression via PERK-CHOP Pathway, Leading to Hepatocyte Death.International journal of molecular sciences · 2019Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Chao ZhangDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center. Jackson, Mississippi (C.Z., X.H., S.R.M., H.Z., S.W., Y.G., W.G., J.M.W., R.J.R., F.F.); Department of Urology, Zhongshan Hospital, Fudan University. Shanghai, China (C.Z., W.G.); and Department of Physiology, Medical College of Wisconsin. Milwaukee, Wisconsin (A.M.G.).
Xiaochen HeDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center. Jackson, Mississippi (C.Z., X.H., S.R.M., H.Z., S.W., Y.G., W.G., J.M.W., R.J.R., F.F.); Department of Urology, Zhongshan Hospital, Fudan University. Shanghai, China (C.Z., W.G.); and Department of Physiology, Medical College of Wisconsin. Milwaukee, Wisconsin (A.M.G.).
Sydney R MurphyDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center. Jackson, Mississippi (C.Z., X.H., S.R.M., H.Z., S.W., Y.G., W.G., J.M.W., R.J.R., F.F.); Department of Urology, Zhongshan Hospital, Fudan University. Shanghai, China (C.Z., W.G.); and Department of Physiology, Medical College of Wisconsin. Milwaukee, Wisconsin (A.M.G.).
Huawei ZhangDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center. Jackson, Mississippi (C.Z., X.H., S.R.M., H.Z., S.W., Y.G., W.G., J.M.W., R.J.R., F.F.); Department of Urology, Zhongshan Hospital, Fudan University. Shanghai, China (C.Z., W.G.); and Department of Physiology, Medical College of Wisconsin. Milwaukee, Wisconsin (A.M.G.).
Shaoxun WangDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center. Jackson, Mississippi (C.Z., X.H., S.R.M., H.Z., S.W., Y.G., W.G., J.M.W., R.J.R., F.F.); Department of Urology, Zhongshan Hospital, Fudan University. Shanghai, China (C.Z., W.G.); and Department of Physiology, Medical College of Wisconsin. Milwaukee, Wisconsin (A.M.G.).
Ying GeDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center. Jackson, Mississippi (C.Z., X.H., S.R.M., H.Z., S.W., Y.G., W.G., J.M.W., R.J.R., F.F.); Department of Urology, Zhongshan Hospital, Fudan University. Shanghai, China (C.Z., W.G.); and Department of Physiology, Medical College of Wisconsin. Milwaukee, Wisconsin (A.M.G.).
Wenjun GaoDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center. Jackson, Mississippi (C.Z., X.H., S.R.M., H.Z., S.W., Y.G., W.G., J.M.W., R.J.R., F.F.); Department of Urology, Zhongshan Hospital, Fudan University. Shanghai, China (C.Z., W.G.); and Department of Physiology, Medical College of Wisconsin. Milwaukee, Wisconsin (A.M.G.).
Jan M WilliamsDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center. Jackson, Mississippi (C.Z., X.H., S.R.M., H.Z., S.W., Y.G., W.G., J.M.W., R.J.R., F.F.); Department of Urology, Zhongshan Hospital, Fudan University. Shanghai, China (C.Z., W.G.); and Department of Physiology, Medical College of Wisconsin. Milwaukee, Wisconsin (A.M.G.).
Aron M GeurtsDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center. Jackson, Mississippi (C.Z., X.H., S.R.M., H.Z., S.W., Y.G., W.G., J.M.W., R.J.R., F.F.); Department of Urology, Zhongshan Hospital, Fudan University. Shanghai, China (C.Z., W.G.); and Department of Physiology, Medical College of Wisconsin. Milwaukee, Wisconsin (A.M.G.).
Richard J RomanDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center. Jackson, Mississippi (C.Z., X.H., S.R.M., H.Z., S.W., Y.G., W.G., J.M.W., R.J.R., F.F.); Department of Urology, Zhongshan Hospital, Fudan University. Shanghai, China (C.Z., W.G.); and Department of Physiology, Medical College of Wisconsin. Milwaukee, Wisconsin (A.M.G.).
Fan FanDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center. Jackson, Mississippi (C.Z., X.H., S.R.M., H.Z., S.W., Y.G., W.G., J.M.W., R.J.R., F.F.); Department of Urology, Zhongshan Hospital, Fudan University. Shanghai, China (C.Z., W.G.); and Department of Physiology, Medical College of Wisconsin. Milwaukee, Wisconsin (A.M.G.) ffan@umc.edu.
Zhongshan Hospital · CNFudan University · CNMedical College of Wisconsin · USUniversity of Mississippi Medical Center · US
Funding
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M20-HETE-TGF-beta in Hypertension-Induced Renal InjuryR37HL036279 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROMAN, RICHARD J. · 2005 to 2014
$4.0MGenetic determinants of hypertension-induced cerebral vascular dysfunctionR01HL138685 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROMAN, RICHARD J. · 2018 to 2021
$1.9MAdducin, actin cytoskeleton and cognitive impairmentsR01AG057842 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI WILLIAMS, JAN MICHAEL · 2019 to 2023
$1.9MRenal microcirculation and hypertension induced renal injuryR01DK104184 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROMAN, RICHARD J. · 2014 to 2017
$1.8MMechanisms involved in the early development of renal disease associated with prepubertal obesityR01DK109133 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI WILLIAMS, JAN MICHAEL · 2017 to 2021
$1.7MVASA RECTA HEMODYNAMICS IN GENETIC HYPERTENSIONR01HL036279 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI ROMAN, RICHARD J. · 1986 to 2004
$1.3MAnimal model of impaired autoregulation for study of age related vascular cognitive impairmentR21AG050049 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI FAN, FAN · 2016 to 2017
$419kNHLBI NIH HHS R01 HL036279NHLBI NIH HHS R01 HL138685NHLBI NIH HHS R37 HL036279NIA NIH HHS R01 AG057842NIA NIH HHS R21 AG050049NIDDK NIH HHS R01 DK104184NIDDK NIH HHS R01 DK109133NIGMS NIH HHS P20 GM104357
Abstract
Dual-specificity protein phosphatase 5 (DUSP5) is a member of the tyrosine-threonine phosphatase family with the ability to dephosphorylate and inactivate extracellular signal-related kinase (ERK). The present study investigates whether knockout (KO) of
Indexed as
Gene Knockout TechniquesAnimalsChemokine CCL2Down-RegulationDual-Specificity PhosphatasesEpithelial-Mesenchymal TransitionFibrosisGene Expression Regulation, EnzymologicHemodynamicsHypertension, RenalKidney GlomerulusMaleMatrix MetalloproteinasesMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Muscle DevelopmentCcl2 protein, ratChemokine CCL2Dual-Specificity PhosphatasesDusp5 protein, ratMatrix MetalloproteinasesMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Protein Kinase CTransforming Growth Factor beta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.