ArticleHeart (British Cardiac Society)2019
Association of sex and atrial fibrillation therapies with patient-reported outcomes.
Article in Heart (British Cardiac Society), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PaTH Clinical Data Research Network (CDRN) Atrial Fibrillation (AF) Clinician-Patient Partnership Cohort
Physiotherapist Led Exercise Within Cardiac Rehabilitation and Inspiratory Muscle Training and Patients With Paroxysmal Atrial Fibrillation - a Randomized Controlled Trial
Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Mental Health Across the Atrial Fibrillation Continuum: Mechanisms, Outcomes, and Clinical Implications.Life (Basel, Switzerland) · 2026Review
- Preventing atrial fibrillation with SGLT2 inhibitors: time, sex, and substrate.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- Sex differences in hospitalisation and healthcare utilisation for patients with atrial fibrillationInternational journal of cardiology. Heart & vasculature · 2025Article
- Observational
- Stroke risk in women with atrial fibrillation.European heart journal · 2024Article
- Generalized anxiety is a predictor of impaired quality of life in patients with atrial fibrillation: Findings from the prospective observational ARENA study.Journal of psychosomatic research · 2024Observational
- Gender-Based Clinical, Therapeutic Strategies and Prognosis Differences in Atrial Fibrillation.Journal of cardiovascular development and disease · 2023Article
- Sex Differences in Atrial Fibrillation.Current cardiology reports · 2023Review
- Quality of life and mental health of women who had cardiac disease in pregnancy and postpartum.BMC pregnancy and childbirth · 2022Article
- Gender, ethnic, and socioeconomic differences in access to catheter ablation therapy in patients with atrial fibrillation.Frontiers in cardiovascular medicine · 2022Article
- Fear of Recurrence of Atrial Fibrillation: Translating a Cancer Fear Model to the Atrial Fibrillation Patient Experience.Frontiers in psychiatry · 2022Review
- Sex differences in atrial fibrillation: patient-reported outcomes and the persistent toll on women.American journal of preventive cardiology · 2021Article
- Impact of Catheter Ablation on Quality of Life and Healthcare Utilisation.Arrhythmia & electrophysiology review · 2021Review
- Racial and Sex Disparities in Anticoagulation After Electrical Cardioversion for Atrial Fibrillation and Flutter.Journal of the American Heart Association · 2021Article
- Review
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Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesWomen report higher atrial fibrillation (AF) symptom severity and receive less AF therapies than their male counterparts. It is understudied if differences in AF therapies received explains sex differences in AF symptom severity. We investigate the impact of sex and AF therapies on patient-reported outcomes.
methodsParticipants were recruited (n=953) across four academic medical centres with an AF diagnosis and age ≥18 years. Patient-reported outcomes (AF symptom severity, AF-related quality of life, functional status and emotional status) were determined by biannual surveys. We performed multiple linear regressions on propensity-matched cohorts to determine the association of AF therapies and sex on patient-reported outcomes.
resultsOur study population (n=953) was 65% male (n=616), 93% white (n=890) and 72 (±10) years old. Individuals receiving rate control therapy reported comparatively lower AF-related quality of life (-7.22, 95% CI -11.51 to -2.92) and poorer functional status (-3.69, 95% CI -5.27 to -2.12). Individuals receiving rhythm control strategies did not report significantly different patient-reported outcomes. Women were more likely to report poorer functional status (-2.63, 95% CI -3.86 to -1.40) and poorer AF-related quality of life, higher anxiety (2.33, 95% CI 1.07 to 3.59), higher symptoms of depression (1.48, 95% CI 0.31 to 2.65) and AF symptom severity (0.29, 95% CI 0.07 to 0.52).
conclusionsFemale sex was associated with comparatively poorer AF symptom severity and quality of life, and this association remained after accounting for AF therapies received. Receiving rate control medication alone was associated with comparatively poorer AF-related quality of life and functional status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.