ArticleThe British journal of ophthalmology2020
Compensation of retinal nerve fibre layer thickness as assessed using optical coherence tomography based on anatomical confounders.
Article in The British journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Explainable Multimodal OCT and OCTA Analysis Reveals Structural and Vascular Features of Mild Glaucoma Across Ethnicities.Investigative ophthalmology & visual science · 2026Observational
- Reproducibility of VF, OCT, and OCTA in Glaucoma: A Prospective Multi-Visit Study.Translational vision science & technology · 2026Article
- Normative Variability in Retinal Nerve Fiber Layer Thickness: Does It Matter Where the Peaks Are?Translational vision science & technology · 2025Article
- Longitudinal analysis of retinal and choriocapillaris in patients with multiple sclerosis: a 3-year study.Journal of neurology · 2025Article
- Diagnosis of cognitive impairment and dementia: blood plasma and optical coherence tomography.Brain communications · 2025Article
- Enhancing the structure-function relationship in glaucoma using anatomical compensation of retinal nerve fibre layer.The British journal of ophthalmology · 2024Article
- Comparing Optical Coherence Tomography Angiography Metrics in Healthy Chinese and Caucasian Adults.Journal of personalized medicine · 2024Article
- Evaluation of thickness of individual macular retinal layers in diabetic eyes from optical coherence tomography.Scientific reports · 2024Article
- Assessing the external validity of machine learning-based detection of glaucoma.Scientific reports · 2023Article
- Comparison of machine learning approaches for structure-function modeling in glaucoma.Annals of the New York Academy of Sciences · 2022Article
- A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer's disease.Alzheimer's research & therapy · 2022Article
- A multi-regression approach to improve optical coherence tomography diagnostic accuracy in multiple sclerosis patients without previous optic neuritis.NeuroImage. Clinical · 2022Article
- Combining OCT and OCTA for Focal Structure-Function Modeling in Early Primary Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2021Article
- Distribution and Classification of Peripapillary Retinal Nerve Fiber Layer Thickness in Healthy Young Adults.Translational vision science & technology · 2021Article
- Segregation of neuronal-vascular components in a retinal nerve fiber layer for thickness measurement using OCT and OCT angiography.Biomedical optics express · 2021Article
- A Wide-Field Optical Coherence Tomography Normative Database Considering the Fovea-Disc Relationship for Glaucoma Detection.Translational vision science & technology · 2021Article
- Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis.Scientific reports · 2021Article
- Focal Structure-Function Relationships in Primary Open-Angle Glaucoma Using OCT and OCT-A Measurements.Investigative ophthalmology & visual science · 2020Article
- Comparison of a commercial spectral-domain OCT and swept-source OCT based on an angiography scan for measuring circumpapillary retinal nerve fibre layer thickness.The British journal of ophthalmology · 2020Article
- Age-related changes of individual macular retinal layers among Asians.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsTo compensate the retinal nerve fibre layer (RNFL) thickness assessed by spectral-domain optical coherence tomography (SD-OCT) for anatomical confounders.
methodsThe Singapore Epidemiology of Eye Diseases is a population-based study, where 2698 eyes (1076 Chinese, 704 Malays and 918 Indians) with high-quality SD-OCT images from individuals without eye diseases were identified. Optic disc and macular cube scans were registered to determine the distance between fovea and optic disc centres (fovea distance) and their respective angle (fovea angle). Retinal vessels were segmented in the projection images and used to calculate the circumpapillary retinal vessel density profile. Compensated RNFL thickness was generated based on optic disc (ratio, orientation and area), fovea (distance and angle), retinal vessel density, refractive error and age. Linear regression models were used to investigate the effects of clinical factors on RNFL thickness.
resultsRetinal vessel density reduced significantly with increasing age (1487±214 µm in 40-49, 1458±208 µm in 50-59, 1429±223 µm in 60-69 and 1415±233 µm in ≥70). Compensation reduced the variability of RNFL thickness, where the effect was greatest for Chinese (10.9%; p<0.001), followed by Malays (6.6%; p=0.075) and then Indians (4.3%; p=0.192). Compensation reduced the age-related RNFL decline by 55% in all participants (β=-3.32 µm vs β=-1.50 µm/10 years; p<0.001). Nearly 62% of the individuals who were initially classified as having abnormally thin RNFL (outside the 99% normal limits) were later reclassified as having normal RNFL.
conclusionsRNFL thickness compensated for anatomical parameters reduced the variability of measurements and may improve glaucoma detection, which needs to be confirmed in future studies.
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