ArticleMicrobiome2019
Microbial community drivers of PK/NRP gene diversity in selected global soils.
Article in Microbiome, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Microbial Consortium ofPlants (Basel, Switzerland) · 2025Article
- Microbial secondary metabolites: advancements to accelerate discovery towards application.Nature reviews. Microbiology · 2025Review
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- A review on comparative analysis of marine and freshwater fish gut microbiomes: insights into environmental impact on gut microbiota.FEMS microbiology ecology · 2025Review
- Exploring the biosynthesis potential of permafrost microbiomes.Environmental microbiome · 2024Article
- Phosphorus availability influences disease-suppressive soil microbiome through plant-microbe interactions.Microbiome · 2024Article
- The impacts of ecological disturbances on the diversity of biosynthetic gene clusters in kauri (Agathis australis) soil.Environmental microbiome · 2024Article
- Shotgun metagenomic insights into secondary metabolite biosynthetic gene clusters reveal taxonomic and functional profiles of microbiomes in natural farmland soil.Scientific reports · 2024Article
- Unlocking the biosynthetic potential and taxonomy of the Antarctic microbiome along temporal and spatial gradients.Microbiology spectrum · 2024Article
- Diversity and distribution of biosynthetic gene clusters in agricultural soil microbiomes.mSystems · 2024Article
- Article
- Non-ribosomal peptide synthase profiles remain structurally similar despite minimally shared features across fungus-farming termite microbiomes.ISME communications · 2024Article
- TerrANTALife 1.0 Biodiversity data checklist of known Antarctic terrestrial and freshwater life forms.Biodiversity data journal · 2024Article
- Succession of microbial community composition and secondary metabolism during marine biofilm development.ISME communications · 2024Article
- Present and future outlooks on environmental DNA-based methods for antibiotic discovery.Current opinion in microbiology · 2023Review
- Global analyses of biosynthetic gene clusters in phytobiomes reveal strong phylogenetic conservation of terpenes and aryl polyenes.mSystems · 2023Article
- Mining Biosynthetic Gene Clusters inMicroorganisms · 2022Article
- Soil substrate culturing approaches recover diverse members of Actinomycetota from desert soils of Herring Island, East Antarctica.Extremophiles : life under extreme conditions · 2022Article
- Genomic and Chemical Decryption of the Bacteroidetes Phylum for Its Potential to Biosynthesize Natural Products.Microbiology spectrum · 2022Article
- Nutrient Availability Shifts the Biosynthetic Potential of Soil-Derived Microbial Communities.Current microbiology · 2022Article
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Authors and funding
10 authors.
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Abstract
backgroundThe emergence of antibiotic-resistant pathogens has created an urgent need for novel antimicrobial treatments. Advances in next-generation sequencing have opened new frontiers for discovery programmes for natural products allowing the exploitation of a larger fraction of the microbial community. Polyketide (PK) and non-ribosomal pepetide (NRP) natural products have been reported to be related to compounds with antimicrobial and anticancer activities. We report here a new culture-independent approach to explore bacterial biosynthetic diversity and determine bacterial phyla in the microbial community associated with PK and NRP diversity in selected soils.
resultsThrough amplicon sequencing, we explored the microbial diversity (16S rRNA gene) of 13 soils from Antarctica, Africa, Europe and a Caribbean island and correlated this with the amplicon diversity of the adenylation (A) and ketosynthase (KS) domains within functional genes coding for non-ribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), which are involved in the production of NRP and PK, respectively. Mantel and Procrustes correlation analyses with microbial taxonomic data identified not only the well-studied phyla Actinobacteria and Proteobacteria, but also, interestingly, the less biotechnologically exploited phyla Verrucomicrobia and Bacteroidetes, as potential sources harbouring diverse A and KS domains. Some soils, notably that from Antarctica, provided evidence of endemic diversity, whilst others, such as those from Europe, clustered together. In particular, the majority of the domain reads from Antarctica remained unmatched to known sequences suggesting they could encode enzymes for potentially novel PK and NRP.
conclusionsThe approach presented here highlights potential sources of metabolic novelty in the environment which will be a useful precursor to metagenomic biosynthetic gene cluster mining for PKs and NRPs which could provide leads for new antimicrobial metabolites.
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