ArticleBMC infectious diseases2019
Underlying mechanisms of leprosy recurrence in the Western Amazon: a retrospective cohort study.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Systematic Review of Survival Analysis in Leprosy Studies-Including the Following Outcomes: Relapse, Impairment of Nerve Function, Reactions and Physical Disability.International journal of environmental research and public health · 2022Pooled it
- SARS-CoV-2 Detection and Persistence in a Remote Amazonian Settlement.Journal of tropical medicine · 2025Article
- Challenges Experienced and Observed during the Implementation of Leprosy Strategies, Sidama Region, Southern Ethiopia: An inductive thematic analysis of qualitative study among health professionals who working with leprosy programs.PLoS neglected tropical diseases · 2023Article
- Case Report: Necrotizing Erythema Nodosum as a Manifestation of Lepromatous Leprosy Relapse 50 Years after the Initial Infection.The American journal of tropical medicine and hygiene · 2023Article
- Article
- Assessment of neuropathic pain in leprosy patients with relapse or treatment failure by infrared thermography: A cross-sectional study.PLoS neglected tropical diseases · 2021Article
- Low rate of relapse after twelve-dose multidrug therapy for hansen's disease: A 20-year cohort study in a brazilian reference center.PLoS neglected tropical diseases · 2021Observational
- Geospatial epidemiology of leprosy in northwest Bangladesh: a 20-year retrospective observational study.Infectious diseases of poverty · 2021Observational
- Relapse in leprosy and drug resistance assessment in a tertiary hospital of the state of Espírito Santo, Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2021Observational
- Magnitude and temporal trends of leprosy relapse in the state of Ceará, Brazil in the period 2001-2018.Revista da Sociedade Brasileira de Medicina Tropical · 2021Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe multidrug therapy (MDT) for leprosy treatment adopted by Brazil in the 1990s was important for reducing leprosy in the country; however, recurrent cases remained problematic. Mechanisms involved in leprosy recurrence are heterogeneous and can be sorted into three groups: insufficient therapy, bacillary persistence and new infections. This study aimed to analyse the time interval of leprosy recurrence in relation to the therapeutic scheme in the state of Acre. The hypotheses were as follows: 1) treatments (a) rifampicin, ofloxacin and minocycline (ROM) and (b) dapsone (DDS) have a short leprosy recurrence time, 2) treatments based on MDT have a long leprosy recurrence time, 3) there is a dose-response relationship between MDT and the time interval between leprosy episodes.
methodsThis retrospective cohort study included 201 patients with a second episode of clinical leprosy at the reference centers for leprosy control in the state of Acre. Exposure was the type of therapeutic scheme as follows: 1) ROM, 2) DDS, 3) MDT
resultsThe 201 patients studied during this retrospective follow-up resulted in a total of 224 cases of recurrent leprosy. Incidence rate ratios within this therapeutic scheme were as follows: 3.3 (2.39, 4.2; ROM/MDT
conclusionsNew infection is an important-yet neglected-mechanism in leprosy recurrence in the state of Acre and can challenge the leprosy elimination plan in Brazil. MDT with few doses might be associated with leprosy recurrence due to insufficient therapy or bacillary persistence.
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