Evidence map›Paper›PMID 31118027›Full record

ArticleJournal of translational medicine2019

Soluble glucocorticoid-induced tumor necrosis factor receptor regulates Helios expression in myasthenia gravis.

Yi Li, Shumei Yang, Zhibin Li, Huanyu Meng, Wanling Jin, Huan Yang, Weifan Yin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. An angel or a devil? Current view on the role of CD8Journal of translational medicine · 2024
    Review
  3. Article
  4. Coexpression of Helios in Foxp3Disease markers · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yi LiDepartment of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China.
Shumei YangDepartment of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China.
Zhibin LiDepartment of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China.
Huanyu MengDepartment of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China.
Wanling JinDepartment of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China.
Huan YangDepartment of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China. yangh69@126.com.ORCID 0000-0003-1523-0338
Weifan YinDepartment of Neurology, Second Xiangya Hospital, Central South University, 137 People Road, Changsha, Hunan, China. yinweifan1985@csu.edu.cn.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHelios is important for functional and phenotype stability of regulatory T cells (Tregs). However, the role of Helios in autoimmune diseases and its regulation remains unclear. This study aimed to investigate the role of Helios

methodMulticolor flow cytometry was performed to analyze Helios

resultBoth Helios

conclusionThis work demonstrates abnormal changes in Helios

Indexed as

AdultAntigens, CDApyraseCell MembraneFemaleForkhead Transcription FactorsGlucocorticoid-Induced TNFR-Related ProteinGlucocorticoidsHumansIkaros Transcription FactorMaleMyasthenia GravisSolubilityT-Lymphocytes, RegulatoryTumor Necrosis FactorsAntigens, CDApyraseCD39 antigenForkhead Transcription FactorsFOXP3 protein, humanGlucocorticoid-Induced TNFR-Related ProteinGlucocorticoidsIkaros Transcription FactorIKZF2 protein, humanTNFRSF18 protein, humanTNFSF18 protein, humanTumor Necrosis FactorsGITRGITRLHeliosMyasthenia gravisRegulatory T cells

Identifiers

PMID31118027
PMCPMC6530055
OpenAlexW2947160888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.